Meditation Stopper Treatment Of Refractory Tic Disorder Evaluation And Logistic Factors Influencing Factors

Objective1. Visual comparison of Aripiprazole and Jing Xin Zhi Dong recipe in improving the treatment of TD tic movements and emotional,and clear the mechanism of TCM TD is mind disorders, disturbance of liver wind, adverse pulmonary orifices.2.Western medicine treatment of some influencing factors were analyzed TD, while systemic symptoms including sleep, diet, emotional and other aspects of Chinese and Western medicine treatment after comparing TD to compensate YGTSS Ratings for traditional Chinese medicine TD judgment deficiencies, improve the efficacy of traditional Chinese medicine TD evaluation methods.3. The risk factors of intractable tourette disorder logistics analysis, screening the high-risk factors.MethodIn January 2014 --2015 in December Guanganmen hospital of children with TD, select the age of 8-11 years, in line with DSM-IV-TR diagnostic criteria, standards and syndromes, in the course of more than 12 months, YGTSS score between 40-70 points refractory tic children 120 cases before the group is not used, the unused medicine or treatment within the first six months over the western medicine, all chosen by the parents of children enrolled signed get Guanganmen hospital Medical EthicsCommittee approved informed consent.Grouping method:observation group and the control group 60 cases. Research randomized, double-blind double-dummy clinical research methods.Delivery method:Jing Xin Zhi Dong recipe are made of meditation free fried particles in the form of oral, twice daily; tablets Aripiprazole tablets active ingredient 5mg. oral,twice daily. Jing Xin Zhi Dong recipe group (A) +Aripiprazole tablets simulant, Aripiprazole group (B) group to aripiprazole tablets+ Jing Xin Zhi Dongsimulant,during and after treatment not given other medications.treatment for 12 weeks.Observation methods:children enrolled in each case to fill in the questionnaire risk factors, YGTSS score table, table syndromes;4 weeks,8 weeks and 12 weeks, respectively, follow-up 1, fill YGTSS score sheet during follow-up, TESS, syndromes table;In the 12 weeks of treatment for each patients then blood, urine, liver and kidney function tests.Statistical methods:All tests were performed statistical analyzes with bilateral hypothesis testing, measurement indicators between groups were compared using a t test or Wilcoxon rank sum test was used to compare paired t test or paired rank sum test within the group; count indicator using x 2 test or Fisher’s exact test, grade index using Wilcoxon rank sum testData analysis using SAS 9.2 statistical software package, tic disorder risk factors Logistic regression analysis.Results1.Study included 120 cases of subjects, Traditional Chinese medicine, western medicine group (n= 60), female children six cases, there was no significant difference in gender, age, type of distribution of the syndrome (P> 0.05).2.Safety assessment:B group security check, security check was abnormal in 6 after treatment,accounted for 11.54%, are the electrocardiogram (ecg) tip:sinus arrhythmia, mild clinical abnormalities, three days after the drug was stopped review normal electrocardiogram (ecg);A group security checks, no abnormal after treatment.Side effects:A group appear nausea in 1 case, the child is the first time to take medicine, parents insist on medication, medication after 3 agent, the symptoms disappear, clinical judgment does not belong to adverse reactions;B group, the adverse event in 4 cases, accounting for 7.6%, including 2 cases in the medicine appear dizziness, drowsiness, within 24 hours,adhere to the medication for three days not to appear afore-mentioned symptoms, mild adverse reactions;2 cases of abdominal pain, parents insist on drug use 2 days did not appear again, for mild adverse reactions.3.YGTSS reduced rate:4 weeks of treatment in improving vocal tic frequency terms, A group than the B group (P<0.05);8 weeks of treatment in the number of motor tics, frequency, total motor tics and vocal tic frequency, frequency, improving the overall vocal tic terms, A group meditation ended better than B group (P <0.05);12 weeks of treatment reducing rates of view, the number of motor tics, interference, and vocal tic frequency, frequency, total damage rate, A group is better than B group (P<0.05);4.TCM symptoms improvement:4 weeks of treatment, A group in improving emotion, sleep, enuresis, nasopharynx health aspects, significantly better than the B group;8 weeks of treatment, A group in improving mood, emotion, sleep, sweating aspect significantly better than the B group. Among them, the emotional effect is more significant, urgent trouble irritability (P<0.001);12 weeks of treatment, B group in improving heart, liver Department of Pulmonary symptoms, the effect is more prominent. Heart symptoms:sensitivity (P<0.0001), Yi grievances (P<0.0001), likes to laugh (P<0.0001) sleep is not real (P<0.0001), hepatic system symptoms:trouble anxious irritability (P<0.0001), suffering children sentiment improved significantly; pulmonary system:the swollen tonsils (P<0.0001), to ease the symptoms of the nasopharynx and improved. Further improvement in terms of tics in children with recurrent oral ulcers, Jing Xin Zhi Dong is more obvious group (P= 0.0469);5.Comprehensive Clinical Evaluation:Treatment of 4 weeks, effective A group 20 cases (33.33%),40 cases (66.67%), B group effectively and 23 cases (38.33%), invalid 37 cases (61.67%);Treatment for 8 weeks effective A group 56 cases (93.33%), 4 cases were ineffective (6.67%), B group of 49 cases (81.67%), invalid 11 cases (18.33%);Treatment for 12 weeks, A group 28 cases (46.67%). effective 30 patients (50%), invalid in 2 cases (3.33%).A group total effective rate was 96.76%, B group of 13 cases were markedly improved (21.67%).39 cases (65%).invalid 8 cases (13.33%).B group total effective rate was 87.67%. A group is superior to western medicine.6.Multiple factors logistics regression analysis shows that:Air pollution, course (> 12 months), began to age (> 5 years), the guardian (grandparents), learning initiative, appetite, sleep, urinate, mood swings (TV time long) impact on the severity of tic disorders have statistical significance. Conclusion 1. Aripiprazole, Jing Xin Zhi Dong recipe can improve refractory tic disorders, but Chinese medicine security effectiveness is higher,:and in the movement to improve the twitching movements, the number, frequency, and integrated efficacy of TCM symptoms vocal action, the meditation group was superior to the Aripiprazole group.2. It clarifies the TD of TCM is distraught, disturbance of liver wind, adverse pulmonary orifices;Verify that the "theory of governance from the heart" tic disorder scientific and practical,Chinese medicine effective treatment of clinical pathway tic disorder.3. On the risk factors of refractory tic disorders were analyzed many factors logistics,shows that air pollution levels, course (> 12 months), began to age (> 5 years), the guardian (parents), learning initiative, appetite, sleep, urinate, mood swings (TV time long) for high risk factors of the refractory tic disorders.