The Significance Of Treg,T Lymphocytes Subsets And IL-17,IL-23 In Multiple Myeloma

Multiple myeloma is a malignant plasma cell proliferative diseases, and its pathogenesis is complex, unclear etiology.Gene mutation and immune dysfunction is closely related with the disease.CD4+CD25high/+CD127low/- regulatory T cells is a special kind of cell populations in playing immunosuppressive effects through a variety of ways in the immune tolerance process play an important role.IL-17 and IL-23 are mainly by Th17 cells secretion and play a important role of cytokines, and secretion of these two cytokines increase mainly by Treg / Th17 regulation, and aslo exist Treg / Th17 imbalance of proportion in MM patients.The treatment of MM patients although a certain effect by chemotherapy and bone marrow transplantation,but the function of body organ damage and long-term survival is not very satisfactory.In this study, we further explore the changes of T lymphocyte subsets, Treg cells, IL-17 and IL-23 in patients with MM, and provide a new guidance for the treatment of MM disease.Objective: To detect the levels,clinical significance and their mutual relations of T lymphocyte subsets,CD4+CD25high/+CD127low/- regulating T cell(Treg),IL-17 and IL-23 in the peripheral blood of multiple myeloma patients.Results: NK cells and CD8+T cells in untreated proup was significantly higher than control group.Compared with control group,CD4+/CD8+T lymphocyte ratio was lower(P <0.05).The level of Treg in the untreated group and ineffective group was higher than control group, but also higher than effective group(P <0.05).In the stage of disease, the III phase in the untreated group was significantly higher than that of I and II, and the difference was statistically significant(P<0.05).Application of ELISA method for detecting the level of IL-17 and IL-23 in newly diagnosed MM patients,the results showed that IL-17 and IL-23 in the initial treatment group were also higher than control group, and it was negatively correlated with the level of Treg.Conclusion: Abnormal expression of T lymphocytes subsets,Treg,IL-17 and IL-23 in MM patients may be related to tumor burden, disease progression and prognosis.This also can be used as indicators of prognosis and potential therapeutic evaluation with a guiding value.