Receptor Interacting Protein Kinase 1 Expression In Esophageal Squamous Carcinoma And Clinical Significance

Objective The investigation of the expression and clinical significance of Receptor interacting protein kinase 1(RIP1) in esophageal squamous cell carcinoma.Methods Immunohistochemistry and Western blot analysis were applied to detect and analyze the expression of RIP1 in cancer tissue and the relevant pericarcinomatous tissue, as well as in the corresponding normal esophageal mucosa in 100 cases of ESCC patients.Results RIP1 expression levels in 71% of cases were demonstrated to be the highest in cancer tissue, then in pericarcinomatous tissue and normal esophageal mucosa in sequence, with statistical significance(P<0.05). 20% of cases indicated that expression of RIP1 in pericarcinomatous tissue relating to esophageal squamous carcinoma was higher than that in cancer tissue and normal esophageal mucosa orderly(P<0.05).The investigated up-regulated expression of RIP1 in cancer tissue was proved to be relevant with TNM stage, pathologic grade and lymph node metastasis(P<0.05), while it was not associated with sex and age. The up-regulated expression of RIP1 in pericarcinomatous tissue was suggested to be corresponding to invasion depth and TNM stage(P<0.05), but not to sex, age lymph node metastasis or pathological grading.Conclusion The up-regulated expression of RIP1 in esophageal squamous carcinoma was supposed to be relevant to pathological grading, TNM stage and prognosis, which also was effective in the genesis and development of esophageal squamous carcinoma.