The Effects Of Early Fluid Resuscitation On Prognosis In Severe Acute Pancreatitis: A Meta-analysis

Objective: The effect of fluid resuscitation on the prognosis of patients with severe acute pancreatitis was evaluated in the first 24 h. And to explore the incidence of different early fluid resuscitation method and mortality, organ failure rate, abdominal compartment syndrome, the relationship between the rate and provide a scientific basis for the treatment of severe acute pancreatitis patients with early fluid resuscitation.Methods: Computer retrieval Chinese data medical literature database(CBM), VIP database of Chinese science and technology periodicals(VIP), Wanfang digital periodical full text database and China Journal Full-text Database(CNKI), Pub Med, EMBASE, Cochrane Library control test database development and table of severe acute pancreatitis patients with early fluid resuscitation therapy related literature. According to the NOS evaluation and screening of qualified clinical control trials, into the research data using Rev Man5.3 software for Meta analysis.Results: Into 12 literatures 1577 patients: a meta analysis. Results show that limited fluid resuscitation rate of 12.4% 30/242 below full capacity fluid resuscitation rate of 34.9% 60/172.(OR:0.26, 95% CI, 0.15-0.43, P < 0.000 01). In organ function failure occurrence rate of limited fluid resuscitation(20.9% 68/326) below full capacity fluid resuscitation 53.1% 104/196.(OR:0.13, 95%CI:0.08-0.22, P < 0.000 01) and abdominal compartment syndrome occurrence rate of limited fluid resuscitation for 16.8%(26/155) below full capacity fluid resuscitation 47.4% 46/97.(OR:0.19, 95%CI:0.10-0.38, P < 0.000 01). The recovery rate of 11.4%(10/88) was 23.8%, and lower than that of pure crystal fluid resuscitation(19/80),(OR:3.64, 95%CI:1.42-9.33, P=0.007).Conclusion: Limited fluid resuscitation may be an appropriate early fluid resuscitation in patients with severe acute pancreatitis. In mortality and organ failure occurrence rate and abdominal compartment syndrome was significantly improved compared with the other methods for fluid resuscitation, in early fluid resuscitation in treatment to give appropriate colloid composition can reduce mortality and improve the prognosis of the patients.