Epilepsy Brain Network Analysis Method And Application Research Based On Magnetic Resonance

Idiopathic generalized epilepsy(IGE)is a kind of epileptic disorders that does not have any apparent cause or detectable brain lesions, and the neurological basis for its associated cognitive impairments remains unknown. Generalized tonic clonic seizures(GTCS)is one of the most important subset of IGE, which presents typical seizure symptoms of muscle rigidity, violent muscle contractions of the entire body, and loss of consciousness. At present, many studies have found that the brain is organized by a number of large scale intrinsic connectivity networks(ICNs). These are distributed brain regions that exhibit coherent activity, and which are reliably detected. The intrinsic connectivity networks mainly includes the sensorimotor, visual, dorsal and ventral attention, limbic, frontoparietal and default network. Most of the studies only focus on the analysis of abnormal connections within the individual network, or only study the abnormal situation of the individual brain regions, but the interaction between the large scale network and the interaction model is seldom concerned.Therefore, the study introduces the network contingency analysis method to investigate the interaction between and within these intrinsic connectivity networks of the functional and structural brain connectivity networks in IGE-GTCS patients. The study found a similar connectivity alteration of the functional and structural connectivity networks. In the functional connectivity networks, the IGE-GTCS patients showed a decreased functional connectivity within the dorsal attention and default network, and exhibited decreased connectivity between the sensorimotor and ventral attention network, between the limbic and default network, and showed increased connectivity between the dorsal and ventral attention and default network. In addition, the functional connectivity of these abnormalities exhibited a different degree of correlation with epilepsy duration in patients. In the structural connectivity networks, the IGE-GTCS patients showed a decreased structural connectivity within the visual, dorsal attention and default network, and exhibited decreased connectivity between the sensorimotor and limbic network, between the sensorimotor, visual, dorsal attention, limbic and default network. And the structural connectivity of these abnormalities exhibited negative correlations with the duration in IGE-GTCS patients. And these alterations of IGE-GTCS patients may be affected by the long-term neuropsychological and cognitive impairments, such as memory, attention, language and executive dysfunctions.