Study On The Treatment Of Chronic Superficial Gastritis Treated With Jin Qi Capsule And Its Main Effect

Objective: A comprehensive understanding of chronic superficial gastritis disease name, etiology and pathogenesis, syndrome type, treatment.To study the anti-inflammatory and analgesic effects of Jin Qi capsule and its effect on the treatment of chronic superficial gastritis.method:(1)Theoretical research: summary induction of CSG name of disease, etiology and pathogenesis, syndrome type, treatment treatment, and to explore the Jinqi Capsules in the treatment of CSG and law basis.(2)Experimental study:(1)Anti inflammatory experiment: the rats were injected with a concentration of 1%- Jiao-fork- dish glue around the ankle joint.(2)Analgesic experiment: the concentration of0.6% acetic acid solution was injected into the mice by intraperitoneal injection,counting the number of 30 min in the rat and the time of the first torsion of the body.(3)The mechanism of experiment: Take sodium deoxycholate and ethanol repeated stimulation of the rat model of CSG was established. Choosing model for replication in the success group rats, were randomly divided into two groups, after the end of the experimental period, respectively, for the determination of acidity PH and pepsin activity, under the microscope observation of gastric mucosa tissue structure and content determination of interleukin 1 beta and interleukin- 8 and prostaglandin E2(PGE2).Results: Jin Qi capsule can obviously inhibit the swelling of the rat’s foot, the middle dose group is the best. The capsule can effectively prolong the latent time of the first time in mice, and can reduce the times of twisting in the 30 min, the high and middle dose group has the best effect, and the analgesic onset time is related to the dose. Jinqi Capsules to reduce chronic superficial gastritis model rats gastric PH value,reduce the activity of pepsin, reduce the content of rat IL-1, IL-8, increased PGE2 content, which Jinqi Capsules dose effect is the most stable.Conclusion: Jinqi Capsules in the high dose group of rat foot dactylitis disease suppression effect is very significant, Jinqi Capsules high and middle dose in mice with analgesic effect and the dose of the analgesic onset time and Jinqi Capsules has a great relationship. Jinqi Capsules middle dose group can control inflammation of the gastric mucosa, pathological changes in the prevention and treatment of gastric tissue, reduce PH value of gastric juice, reduce the activity of pepsin, reduce pathogenic factors, reduce IL-1, IL-8 levels, and increased PGE2 content.