Association Of Peripheral Monocyte Count And Recent Prognosis After Surgery Of Hypertensive Intracerebral Hemorrhage

Background:The prognosis of hypertensive intracerebral hemorrhage(HICH) is poor.There are many factors affecting the prognosis of HICH. The secondary injury after intracerebral hemorrhage is the main part of brain injury, and is also a current hot research topic. Monocyte maybe one of the important factors that is associated with brain damage after hypertensive intracerebral hemorrhage(HICH). This study was designed to explore the relationship between monocyte and 30-day case fatality after surgery of HICH.Methods: In this retrospective study, the patients’ data was identified from two hospitals(The First Affiliated Hospital of Anhui Medical University, The Chaohu Affiliated Hospital of Anhui Medical University) from January 2012 to March 2014. All the patients had surgery within 12 hours of symptom onset. Other cofactors including sex, age, GCS, volume of hematoma, location, initial hemoglobin, total white blood cell(WBC) count, absolute neutrophil count(ANC), absolute monocyte count(AMC) were collected too. The association between blood cell and volume was determined using linear regression. The blood cell counts and 30-day case fatality was determined using logistic regression.Results: 341 cases were collected. Of the all patients, 176 cases were male and 165 cases were female, mean age was(52.0 ± 7.9), 209 cases were located in the basal ganglia and 132 cases in the brain lobe, 99 cases were combined with intraventricular hemorrhage, mean volume was(60.68±12.46) ml. Higher initial WBC and ANC were associated with higher volume, but AMC was not. Peripheral WBC, ANC and AMC were sustained rising after surgery comparing to admission. They ran up to peak at 3d and decreased normal at 7d after operation. AMC was associated with 30-day case fatality(OR=6.27,95%CI,1.07-36.89,p=0.04) adjusted for age,, location, and volume.Conclusions: Inflammation persist after surgery of HICH. There is an association between AMC and 30-day case fatality in HICH. To intervene the monocyte-mediated pathways maybe an effective target.