The Relationships Between Iron,Copper,Zinc,Cadmium,Selenium, Folic Acid Contents In Serum And Uyghur Cervical Cancer

Objective: This study aims at linking the trace elements Iron, Copper, Zinc,Cadmium, Selenium and Folic acid status of an organism, assessed by serum analysis,with the occurrence and development of HPV infection and cervical cancer in Uyghur women. Methods: Serum samples were collected from 217 HPV infected women and from 106 HPV negative women as control group according to the Care HPV test. At the same time, Serum samples were divided into two groups according to histo-pathological test as case group consisted of 65 patients with high grades of cervical disease( ≥CINII)and control group consisted of 258 chronic cervicitis. Mineral element analysis of serum was performed using by Graphite Furnace Atomic Absorption Spectrometry.Results: 1.There are statistically differences in ages, education level, first marriage age,first childbirth age, births number, marriage number etc between HPV positive group and negative group as well as between experimental group and control group(p<0.05).2.The levels of Folic acid and Selenium in HPV infected group were significantly lower than HPV negative group(p<0.05).3.There is a certain relationship between high grades of cervical disease in Xinjiang region in Bachu county and the trace elements of Cu, Se,Fe,Zn and Folic acid(p<0.05).Conclusion: It seems safe to conclude that there is certain relationship between the contents of selenium, folic acid in serum and HPV infection and that these two elements may the protective factor for HPV infection. This survey confirmed that high level of serum copper is a risk factor for pre-cancer lesions and cervical cancer. Supplementation of right amount of trace elements may could help the treatment of pre-cancer lesions and HPV infection.