The Relationship Between REGγ And E-cadherin And The Mechanism Of Tumor Cell Migration Regulated By REGγ

Now the proteasome activator REGy functional studies have been gradually improved. After REGy was reported to be highly expressed in thyroid cancer, colon cancer, lung cancer and breast cancer, our lab also found its high expression in gastric cancer, ovarian cancer, renal cancer and other cancers. Moreover, with the increase of the degree of cancer malignancy, the REGy expression level gradually increased. So we like to know whether REGy plays an important role in the process of cancer malignant development. Here, for the first time we found REGy can promote a variety of tumor cell migration by transwell experiment. Then, we explored its molecular mechanism and found:REGy downregulated E-cadherin mRNA level. Further molecular mechanism investigation showed that REGγ upregulated E-cadherin transcription repressors Snail2 and Zeb2 through TGFβ signaling pathway. Besides, we found REGγ can degrade endogenous Smurf2. Therefore, we propose a regulatory mechanism:REG y regulate E-cadherin through its degradation of Smurf2 which impact Smad-dependent TGFp signaling pathway. These findings provide new ideas for cancer therapy.