| Diabetes mellitus(DM) is a disorder of protein and lipid metabolism chronic dise ases secondary to Disturbance of carbohydrate metabolism. Its pathophysiological basis is the body relative or absolute lack of insulin secretion, low insulin action or insulin resistance. DM is the interaction of genetic and environmental factors. In recent years,along with improved living standards, changes in lifestyle, its incidence and prevalenc e showed a rising trend year by year, is increasingly becoming a global public health threat to human health. Sustained hyperglycemia and metabolic disorders can lead to astate of chronic damage to body tissue(especially the eye, kidney, cardiovascular andnervous system), and metabolic disorders can also cause severe ketoacidosis and hype rosmolar coma and other acute complications, which makes the quality of life significa ntly decreased, while threatening our lives. Diabetes is a need for lifelong control of d isease, it is extremely important to effective prevention and control of diabetes and thedevelopment of diabetes complications. Currently comprehensive treatment for diabetestreatment includes glucose-lowering, depressurization, Lipid-regulating, anticoagulation,weight control, improved lifestyle, of which glucose-lowering task throughout life alwa ys diabetics. “glucose-lowering†not only refers to the blood sugar to normal, what bet ter, more stable, less side effects, more revenue to maintain normal blood sugar levelsappear to be more critical. Insulin has a hypoglycemic effect, protect islet function ad vantage, other antidiabetic drugs can not be replaced. Insulin is a pancreatic β cell dys function or the best choice for defects, including type 1 diabetes, and some oral hypog lycemic drugs insulin secretion disorder is difficult to control type 2 diabetes and cons olidation of certain special conditions of hyperglycemia(such as stress hyperglycemia,gestational diabetes, juvenile diabetes, acute metabolic disorders in type 2 diabetes, perioperative type 2 diabetes, tuberculosis and other malnutrition factors combined with typ e 2 diabetes, the combined stroke, heart failure, kidney failure and other serious diseas es type 2 diabetes, etc.). Compared with conventional insulin therapy, intensive insulin regimen to better simulate the normal physiologic insulin secretion patterns, and more effective in preventing the development of chronic complications of diabetes. Intensive treatment in two ways: Insulin pump therapy(CSII) and multiple daily insulin injection s(MSII). In recent years, the importance of the way in which the insulin pump for m ore attention.Objective To compare clinical efficacy of intensive therapy by continuous subcuta neous insulin infusion(CSII) and multiple subcutaneous insulin infusion(MSII) in the tre atment in type 2 diabetes mellitus. Methods Sixty patients with type 2 diabetes mell itus was divided into two groups. One was continuous subcutaneous insulin infusion(C SII), using insulin pump with Novolin R. the other was multiple subcutaneous insulin i nfusion(MSII), using Novolin R before meals and Novolin N bedtime. The whole day blood glucose were monitored, and glucose target time, insulin dosage and hypoglycem ia incidence were compared in the two groups before and after treatment. Results C ompared with MSII group, Shorter target time, lower insulin dosage and lower hypogly cemia incidence were discovered in CSII group(P<0.05). Conclusion Continuous su bcutaneous insulin infusion(CSII) and multiple subcutaneous insulin infusion(MSII) wereeffective treatment for type 2 diabetes mellitus. Therapy of CSII were safety and rapi d, with less insulin dosage, superior to MSII. |
PDF Full Text Request