Observation Of Qiangxin Preparation Clinical Effect On CHF

Objective:Observation in the treatment of the Qiangxin preparation’s rapeutic effect safety and probable mechanism of action on CHF(chronic congestive heart failure) patients and patients whose blood stasis obstructing the collaterals.Method:We select 40 CHF patients from department of cardiology in our hospital, which conform with inclusion and exclusion criteria, divided into two groups,20 cases every group. Patients in the contrast group are treated by conventional treatment of western medicine; while patients in the treatment group use extra Qiangxin preparation.(recipe:Zhi Gancao20g、Dan Fupian10g、Dang Shen20g、Mai Dong10g、Che Qiancao 20g、Dan Shen20g、Ting Li zi20g), dosage of Qiangxin preparation was adjusted according to the specific situation of each patient. One dose of the drug per day, divided into 200ml each to take morning and night, period of treatment being 4 weeks. Observe and compare these two group with index such as heart function, heart color ultrasound (LVIDd,LVIDs,EF)and BNP results. At the same time, the security of the medicine needs to be evaluated.Results:1. Before treatment, these two groups have no significant difference in age, gender, CHF classification, heart color ultrasound and BNP (P>0.05), which enhanced the accuracy and comparability.2. In these two groups, signs of efficacy of integration that of syndromes of traditional Chinese medicine and symptoms of Western medicine in patients is significantly lower than before the treatment. (P<0.05). Moreover, signs of efficacy of integration that of syndromes of traditional Chinese medicine and symptoms of Western medicine in treatment group is significantly lower than that of contrast group. (P<0.05)3. Cardiac function overall efficacy comparison:These two groups have no significant difference in the total effective rate.The treated group patients was 90.00%; the controlled group was 70.00%(P>0.05).4. Hemodynamic comparison:Heart Color Ultrasound:EF of treatment group has increased more significantly (P<0.05), but the EF of contrast group has no remarkable difference (P>0.05); LVIDd and LVIDs of treatment group has decreased more significantly (P<0.05), but the contrast group has no remarkable difference (P>0.05);5. BNP comparison:BNP of both group has decreased more than that of before the treatment (P<0.05). BNP of treatment group has decreased more significantly than the controlled group (P<0.05).6. Adverse Reactions Observation:We have examined and record liver and kidney function before and after the treatment period, and we find no abnormal volatility.Conclusion:1.By comparison, it is obvious that patients in treatment group recovers better than in contrast group, cutting down LVIDd and LVIDs, improving EF, improving hemodynamic effect. With combination of traditional Chinese and Western medicine treatment is better than pure Western medicine treatment.2. The Qiangxin preparation may treat well on the abnormalities of neuroendocrine regulation system to decrease BNP.3.We have examined and recorded liver and kidney function during the treatment period, and find no abnormal volatility. Therefore, the combination treatment of conventional western medicine and Qiangxin preparation have no significant side effects, which is worth the clinical promoted use.