The Relationship Between The False-negative Result Of TET And The Diameters Of Coronary Arteries

ObjectiveAs a common tool for the primary screening of coronary artery disease, TET has been reported to have false-negative results sometimes, i.e., the result of TET was negative whereas the results of coronary angiography indicated the presence of coronary artery disease. The mechanism of the false-negative result of TET still remains unclear. We assumed that the diameters and the reserve function of coronary arteries might be related to it, and aimed to testify this assumption in this study.Methods:207 patients evaluated by TET and later diagnosed as CAD by coronary angiography were retrospectively studied. Patients were divided into false-negative and true-positive groups according to the results of TET. Baseline characteristics according age, BMI, GFR, the presence of hypertension, diabetes and hyperlipidemia, and the parameters of coronary artery including the luminal diameters of coronary arteries, the location and degree of coronary artery stenosis were collected and compared between two groups. Logistic regression model was constructed to identify the independent risk factor for the false-negative results of TET.Results:The luminal diameters of coronary arteries for patients in false-negative group were larger than those in true-positive group. The results of logistic regression showed that the luminal diameters of left main trunk, left anterior descending and left circumflex arteries were all independently associated with the false-negative results of TET. Besides, compared with those in true-positive group, the collateral circulation in false-negative group was better developed, with more patients whose stenosis locations in coronary arteries mutually corresponded and lead to the offset of ECG changes.Conclusion:The false-negative results of TET might be related to the large diameters of coronary arteries.