The Clinical Research Of HIT-IMG100P Gastric Motility Detector

ObjectiveThe aim of this study was to explore the gastric dynamic parameters of normal reference value in healthy volunteers, the clinical security and the clinical practicability of the HIT-IMG100P gastric motility detector.Methods1. The HIT-IMG100P gastric dynamic detector and 99mTe chnetium nuclide imaging method were used to test the semisolid gastric dynamic.2. According to the percentages of impedance gastric motility the reference value with 95% CI of the healthy volunteers, to observe the impedance gastric motility in PDS, EPS and PDS overlap EPS patients. To investigate the influences of Domperidone (10 mg, tid X 14d) on the clinical symptoms and impedance gastric motility in FD patients.Results1. The healthy volunteers were not allergic to electrodes in the process of detection by HIT-IMG100P gastric motility detector, after taking the standard meal,1 healthy volunteer appeared on mild abdominal distension; 2 healthy volunteers came about short abdomen ache and self-relieved.2.99mTe chnetium nuclide semisolid gastric emptying imaging method was used to certain the healthy volunteers with normal gastric motility. The 95% CI of the percentages of the low frequency, intermediate frequency, high frequency of gastric impedance in the healthy volunteers with normal gastric motility detected by HIT-IMG100P gastric motility detector were (30.99～33.55)%, (53.11～55.30)% and (12.91～14.15)%,respectively. The 95% CI of the percentages of the low frequency, intermediate frequency, high frequency of gastric electrogram in the healthy volunteers with normal gastric motility detected by HIT-IMG100P gastric motility detector were (29.01～31.74)%, (55.11～57.80)% and (12.96 14.32)%,respectively.3. According to the reference value (95% CI) of the power of impedance gastric motility of the healthy volunteers detected by the HIT-IMG100P gastric motility detector, in the PDS group, the number of the patients with abnormal low, intermediate and high frequency of gastric impedance was 28 (84.85%),24 (72.73%) and 8 (24.24%),respectively; in the EPS group, the number of the patients with abnormal low, intermediate and high frequency of gastric impedance was 17 (70.83%),14 (58.33%) and 9 (37.50%),respectively; in the PDS overlap EPS group, the number of the patients with abnormal low, intermediate and high frequency of gastric impedance was 10 (83.33%),7 (58.33%) and 5(41.67%),respectively.4. After treatment with Domperidone for two weeks, the symptoms of postprandial abdominal distention, early satiety, upper abdominal pain and abdominal burning sensation were significantly improved in Bradygastria group (P<0.05), the clinical symptoms improvement were not obvious in tachygastria group and nomral dynamic group(P>0.05); in the bradygastria group, the percentage of the power of the low frequency of impedance gastric motility was significantly lower, the percentage of the power of the intermediate frequency and high frequency of impedance gastric motility was significantly higher (P<0.05); in the tachygastria and normal dynamic group, the percentage of the power of the low frequency of impedance gastric motility was lower, the percentage of the power of the intermediate frequency and high frequency of impedance gastric motility was higher, but the improvement was not significant (P>0.05)Conclusions1. HIT-IMG 100P gastric motility detector was safe in clinical application.2. The gastric dynamic condition may be more reliable than its symptoms to determine whether or not to use prokinetic agent in FD patients.