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Chronochemotherapy With Paclitaxel,Carboplatin And 5-Fluorouracil For The Patients With Recurrent And/or Metastatic Oral Squamous Cell Carcinoma

Posted on:2016-04-14Degree:MasterType:Thesis
Country:ChinaCandidate:J ChengFull Text:PDF
GTID:2284330482953542Subject:Oral and clinical medicine
Abstract/Summary:PDF Full Text Request
Purpose:To estimate the effect and toxicities of Chronochemotherapy with paclitaxel, carboplatin and 5-fluorouracil in patients who suffered from recurrent and/or metastatic oral squamous cell carcinoma(OSCC).Methods:Retrospective analysis of 49 patients with recurrent and/or metastatic OSCC who underwent palliative treatments with paclitaxel, carboplatin and 5-fluorouracil.The patients were divided into a chronochemotherapy group(28 patients) and a conventional chemotherapy group(21 patients) according to their administration times, the two groups were comprared for effective rate, median overall survial(OS), median progression-free survival(PFS), and the incidence of adverse events.Results:The effective rate and patients’median OS were significantly higher and longer in the chronochemotherapy group than in the conventional chemotherapy group(effective rate 71.43% versus 42.86%, respectively, P< 0.05; and median OS 15.3 months versus 10.6 months,respectively, P<0.05). The global incidence of adverse reaction in the chronomodulatedchemotherapy group was significantly lower than that in the conventional chemotherapy group(46.43% versus 76.19%, P<0.05), with significantly lower incidence of grade 3-4 adverseevents (7.14% versus 33.33%, P<0.05).Conclusion:Chronochemotherapy with paclitaxel, carboplatin and 5-Fu can improve effective rate, prolong survival time and reduce the occurrence of adverse reaction for patients with recurrent and/or metastatic OSCC as compared with conventional chemotherapy.
Keywords/Search Tags:Chronochemotherapy, oral cancer, paclitaxel, carboplatin, 5-fluorouracil
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