The Research On The Relationship Between The Expressions Of Galectin-3 And HBME-1 With The Curative Effect Of ¹³¹I Therapy In The Patients Of Papillary Thyroid Carcinoma

Objective: To research the expressions of Galectin-3, HBME-1 and their clinical significance, and the relationship between their expressions with the curative effect of ¹³¹I therapy in postoperative patients with papillary thyroid carcinoma（PTC）.Methods: The expressions of Galectin-3 and HBME-1 were detect with immunohistochemistry in papillary thyroid carcinoma tissues（47 cases）, and thyroid adenoma tissues（15 cases）, thyroiditis tissues（10 cases）, tuberous strumous tissues（15 cases）, respectively. Moreover, the relationship between their expressions and the curative effect of ¹³¹I therapy in 47 postoperative patients with papillary thyroid carcinoma were analysis.Results1. The positivity expression rate of Galectin-3 was 85.1% in papillary thyroid carcinoma tissues, it’s significantly higher than that in thyroid adenoma（positive 33.3%）, tuberous strumous（positive 20.0%） and thyroiditis tissues（positive 30.0%）（P<0.05）;2. The positivity expression rate of HBME-1 was 89.3% in papillary thyroid carcinoma tissues, it’s significantly higher than that in thyroid adenoma（positive 20.0%）, tuberous strumous（positive 13.3%） and thyroiditis tissues（positive 30.0%）（P<0.05）;3. The positive expressions rate of Galectin-3 and HBME-1 in papillary thyroid carcinoma tissues were not related to their clinical pathological parameters（sex, age, diameter of tumor, lymph node metastasis and TNM staging of tumor）（P>0.05）;4. The positive coincidence rate of Galectin-3 and HBME-1were 95.0%, and the expression rates of Galectin-3 and HBME-1 were positively correlated each other in papillary thyroid carcinoma tissues（rs=0.437, P<0.05）;5. With Galectin-3 as means to detect papillary thyroid carcinoma tissues, the sensitivity, specificity, positive predictive value, negative predictive value, diagnostic accuracy and Kappa were respectively 85.1%、72.5%、78.4%、80.6%、79.3% and 0.58;and with HBME-1 the figures were respectively 89.3%、80.0%、84.0%、86.5%、85.0% and 0.69;Galectin-3 combined with HBME-1（Galectin-3 and HBME-1） the figures were respectively 80.9%、92.5%、92.7%、80.1%、86.2% and 0.72;6. The positive expression rates of Galectin-3 and HBME-1 in papillary thyroid carcinoma tissues were not related to the curative effect of ¹³¹I therapy in postoperative patients with papillary thyroid carcinoma（P>0.05）;7. The curative effect of ¹³¹I therapy in postoperative patients with papillary thyroid carcinoma was also not related to sex, age, diameter of tumor and lymph node metastasis（P>0.05）. But, it was associated with TNM staging of tumor（P<0.05）.Conclusion1. Both Galectin-3 and HBME-1 present high expression in papillary thyroid carcinoma tissues, and the highly expressions of Galectin-3 and HBME-1 were not related to their clinical pathological parameters. It may suggest that they were only related to the occurrence of the papillary thyroid carcinoma, but not associated with the lymph node metastasis. It shows that they have important reference values for the diagnosis and differential diagnosis of papillary thyroid carcinoma.2. The expressions of Galectin-3 and HBME-1 were positively correlated each other in papillary thyroid carcinoma tissues. The union detection of Galectin-3 and HBME-1 can be helpful for increasing the clinical diagnostic accuracy.3. The positive expression rates of Galectin-3 and HBME-1 in papillary thyroid carcinoma tissues were not related to the curative effect of ¹³¹I therapy in postoperative patients with papillary thyroid carcinoma. It shows that the expressions of Galectin-3 and HBME-1 were not related to the prognosis of papillary thyroid carcinoma.