The Effect Of Intensive Insulin Therapy On Blood Coagulation Function In Patients With Newly Diagnosed Type 2 Diabetes

ObjectiveThrough observing and investigating the effect of insulin intensive therapy on coagulation function of the patients with newly diagnosed type 2 diabetes mellitus (Type 2 mellitus diabetes (T2DM), the thesis provides a theoretical basis for the early prevention of vascular disease about the type 2 diabetes mellitus.MethodsThe observation group is composed of 60 type 2 diabetic patients treated in the Department of Endocrinology Clinic of our hospital from September 2013 to September 2015. They are diagnosed as the patients with newly diagnosed type 2 diabetes mellitus according to the standards stipulated by the World Health Organization in 1999. The control group consists of 60 healthy people doing the physical examination in our hospital during the same period. Fasting blood glucose (plasma glucose, FBG), postprandial 2h blood glucose (PBG), Glycated hemoglobin (HbAlc), blood lipid, insulin and blood coagulation index were determined by fasting blood test. Undergoing three-month intensive insulin therapy, the patients in the observation group stopped using exogenous insulin and tested their blood coagulation index, HbAlc,2PBG, FBG and blood lipid through fasting blood. Calculating the function of insulin beta cells (Homaβ) and insulin resistance index (HomaIR), the author compared the changes of the above indexes of the observation group before and after the treatment. And meanwhile, the author compared the observed group with the control group over these indexes.ResultsThere were no significant differences in gender, age, body mass index (BMI) of the observation group and the control group (P> 0.05). Therefore, they are comparable. Before the intensive insulin therapy, the FBG,2PBG, HbAlc, cholesterol (TC), low density lipoprotein (lipoprotein particles by intensive insulin therapy of LDL) and triglycerides (TG) in the observation group were significantly higher than those of control group (P<0.05). High density lipoprotein(HDL) and HOMA beta decreased. HOMA-IR increased. Prothrombin time (PT), activated partial thromboplastin time (APTT) and the international normalized ratio (INR) were significantly shortened. Thromboplastin time (thromboplastin time, TT) had no significant change. After treatment, the FBG,2PBG, HbAlc, TG of the observation group were significantly decreased. HDL increased. Homa beta and HomaIR were dramaticlly improved. APTT, INR and PT were greatly prolonged. There existed obvious differences (P<0.05) before and after the treatment. However, the FBG, HbAlc, TG, LDL, Homa IR of the observation group were higher than those of the control group. Homa beta decreased. HomaIR increased. The PT, APTT, INR and other coagulation indexes were significantly shortened. And the differences were statistically significant (P<0.05).ConclusionThe patients with newly diagnosed type 2 diabetes mellitus lives in a high coagulation condition. The insulin intensive therapy can effectively improve the coagulation function. It is likely that the blood glucose and blood lipid don’t completely return to normal if the patients’coagulation function doesn’t return to normal after insulin intensive therapy,.