Analysis Of Risk Factors Associated With Nonalcoholic Fatty Liver Disease

Object To investigate the detected indicator level changes in the clinical laboratory and risk factors associated with nonalcoholic fatty liver.Methods 228 cases of study objects above fifty years old came from the urban residents checked up in the combination of chinese and western medicine in Xihu district from March to May in 2015. All physical examinees were respectively detected with serum biochemcal markers (ALT, CR, BUN, UA, GLU, TG, TCH), urine routine examination, blood routine examination, ultrasonic examination, stool routine examination, electrocardiogram, X ray, internal or external medicine, physical examination, and cervical smear for female. Another, according to the demand of the study, all physical examinees above fifty years old were added a query survey and some other biochemical indicators.(1)Query survey included smoking history, drinking history, sleeping quality, lunch break, amount of oil, dishes salty or light, career, exercising way, past medical history and medication history. (2) Added biochemical indicators included HCY, AMY, ALP, CA, P, HDL, LDL, LDH, GGT, AST, CK, TB, CK-MB, APOA, APOB, DB, TP, ALB, TBA, AFU, ADA, and all added detected item results were completed in the same day. All study objects were collected according to the following process:(1)After excluding malignant tumor, viral hepatitis with markers positive, chronic mumps, severe renal injury, acute infection or trauma, acute total parenteral nutrition, long-term hormone application history and incomplete information, the collected fatty liver group diagnosed by ulstrasonic each day were named fatty liver group. (2) Non fatty liver group were collected according to fatty liver group and non fatty liver group ratio being two or three. (3)Fatty liver group were divided into nonalcoholic fatty liver group and alcoholic fatty liver group according to volume of alcohol. All study objects were divided into NAFLD group, AFLD group and NFLD group. Of them, AFLD and NFLD were selected as control group. The above three groups objects information of serum biochemical indicator results, blood routine examination, internal or external medicine and query survery were collected, then which were analyzed and compared between NAFLD and control group.Results A total of 228 cases were involved in the study, of them,165 was diagnosed with fatty liver including 120 cases of NAFLD group and forty five cases of AFLD group, with a positive rate of 26.16%, another sixty three cases were selected as non fatty liver group. Statistical results showed that:(1)The prevalence rate of overweight,elevated glucose, hypertriglyceridemia, hyperuricemia and elevated ALT in NAFLD group was higher than in NFLD, while elevated M% and elevated ALT was obviously lower in NAFLD group than in AFLD, and which showed significant differences(P<0.05). Comparison of different groups revealed:1)There was significant differences of biochemical indicators (AFU, DB, GGT, HCY, P, TB, CR, BUN, UA, ALT) and blood routine indicators(RBC, PCT, M%, MCV, MCHC, MCH, HB, HCT) between NAFLD and AFLD group, (P<0.05), another there was also significant differences of biochemical indicators (AMY, APOA, GGT, HCY, HDL, LDH, P, TG, GLU) and blood routine indicators (RDW-SD, MCV, MCH, RBC, HB, MCHC) between NAFLD and NFLD group.2)There was obviously differences for biochemical indicators (ADA, ALB, CK, DB, GGT, HCY, P, TB, TP, CR, BUN, UA, TG) and routine indicators (M%, MCV, MCH, B%)between male and female.3) There existed significant differences for biochemical indicators (DB, HCY, LDL, TBA, ALT, CR, UA) and blood routine indicator of L% in different age groups. (3) Multiple regression analysis showed triglyceride, glucose, Lymphocyte percentage, MCV and BMI were associated with NAFLD (P<0.05).Conclusion Some biochemical or blood routine indicators may play a predicting role during NAFLD treatment or diagnosis. BMI, elevated Lymphocyte percentage, elevated glucose and hypertriglyceridemia are risk factors of fatty liver disease, while elvated MCV is a protective factor.