Effect Of Oral Nutritional Supplement On Malnutrition Status In Patients With Haemodiaiysis: A Meta-analysis Of Randomized Controlled Trials

Objective:To assess the effects of oral nutritional supplement(ONS) on malnutrition status in patients with haemodialysis systemematically and objiectively.Medthods:A computerized search in Cochrane Library, PUBMED, EMBASE, Chinese Biomedical Literature Database(CBM)、China Academic Journal Full-Text Database(CNKI), VIP, and Wanfang Database was performed for revelant randomized controlled trials(RCTs) which investigated the efects of ONS on malnutrition status in patients with haemodialysis. We manually searched the lists of references of eligible literature, topic-related literature and reviews to include any latent studies. Target database were searched, capture citation were screened, data were extracted, and methodological quality of all eligible studies was assessed accordingly by two independent investigators. Any divergences on eligibility of study were solved based on consensus. Then, meta-analysis was performed by using RevMan 5.2.Results:Totally 6 RCTs which included 231 participants were incorporated into the meta-analysis. The meta-analysis results well suggested that oralnutritional supplement effectively elevated blood album concentrations [WMD=1.99,95%CI(1.41,2.57), P<0.00001], prealbuminconcentrations [WMD=34.48,95%CI(25.58,43.39), P<0.00001], no difference was identified in BMI [WMD=0.44,95%CI(-0.39,1.26), P=0.30]、in serum phosphate concentration [WMD=0.08,95%CI(-0.08,0.24), P=0.31]、 in serum potassium concentration [WMD=0.12,95%CI(-0.08,0.32), P=0.26].Conclusion:ONS canimprove some nutrition index in short term but have no effect in BMI, and does not elevated blood potassium and phosphorus concentration, so it’s a kind of safe and effective nutrition intervention method.