A Research About UGT1A1 Gene Polymorphism Among Unconjugated Hyperbilirubinemia Full-Term Neonates In Chongqing Area

Objiective:To explore the UGTIA1 gene polymorphism of unco-n jugated hyperbilirubinemia full-term neonates in Chongqing area.Methods:Totally,347 full-term neonates were enrolled, including 330 unconjugated hyperbilirunermia neonates. According to the jaundice etiology, the unconjugated hyperbilirunermia babies were divided to two groups,210 with clear causes of jaundice and 120 unclear. Meanwhile, the severe jaundice cases were divided to the group undergoing exchange transfusion (213 cases) and the other without transfusion of 117. The UGTIA1 polymorphisms were compared between the groups. Logistic regressin models were employed to analyze the effects of UGTIA1 polymorphisms on full-term neonatal unconjugated hyperbilirubinemia.Results:For the group of unclear-cause jaundice, the total mutate-on incidence, homozygous mutation rate and heterozygous mutation rate of 211G>A was 49.2%,11.7%and 37.5%, respectively, significantly higher than those of the clear-cause group,38.6%,6.2%and 32.4%(P <0.001). Logistic regressin indicated, the OR and 95%CI values of 21 1 G>A mutation associated with the development of unconjugated hy-perbilirubinemia and severe jaundice in full-term neonates were 1.54(3.0 83-8.108) and 2.64(1.278-4.508), respectively. Meanwhile, there was no significant difference in the gene polymorphisms of UGT1A1betwe-en the transfusion and untransmsion groups (P>0.05).Conclusions:211 G>A polymorphism of UGTIA1 maybe involved in the development of etiology unclear full-term neonatal unconjugatd hyperbilirubinemia in Chongqing area.