Haptoglobin Gene Polymorphism And Coronary Heart Disease (CHD)

PART Ⅰ HAPTOGLOBIN GENE POLYMORPHISM AND CORONARY HEART DISEASE (CHD)Haptoglobin is a protein which widely exists in human plasma. It has three different genetic phenotypes, namely Hp1-1, and Hp2-1 Hp2-2. Its main physiological function is to protect the body’s tissues from oxidative stress damage. However, the studies in recent years found that the protective effects among of different genotypes of haptoglobin are distinctive. Hp2-2 has the weakest protective effect, therefore, individuals with Hp2-2 genotype are more vulnerable to the attacks of oxidative stress, atherosclerosis and coronary heart disease (CHD) and have increased mortality of cardiovascular diseases. This provides a new research field for the diagnosis and treatment of coronary heart disease. In This article will provide a review on the relationship between haptoglobin gene polymorphism and coronary heart disease.PART II THE RESEARCH PROGRESS OF ANTIOXIDANTS IN THE TREATMENT OF CORONARY HEART DISEASE(CHD)Oxidative stress damage is one of the important pathogenesis of coronary heart disease, application of antioxidants might be of benefit in patients with coronary heart disease. Some antioxidants have been apply for the prevention and control of coronary heart disease, such as coenzyme Q10, selenium. But many other antioxidants in the treatment of coronary heart disease was still in research, such as the added exogenous haptoglobin can reduce the oxidative stress damage in the acute pathological state, and reduce vascular endothelial injury, then prevent from acute cardiovascular events. Vitamins and polyphenols, lipoic acid and can improve the oxidative stress of the body in vivo and in vitro experiments. So they may be effective in prevention of coronary heart disease. But the results of researches is still controversial. In this review the research progress of application of antioxidants in coronary heart disease will be introduced.