Special Intervention For Antibacterial Agents On The Influence Of Premature Bloodstream Infections

Objective:To analysis the general information and clinical features of premature bloodstream infections and study the implementation and problem of antibacterial agents’ special intervention, which shows the effects on the pathogen and prognosis of premature bloodstream infections.Methods:280 cases in the year of 2010 and 2011(group pre-intervention),267 cases in the year of 2012 (group transition) and 698 cases in the year of 2013 and from January through September of 2014 (group post-intervention) are assessed anew, which are premature infants and diagnosed definitely or doubtfully as sepsis, suppurative meningitis or acute hematogenous osteomyelitis. Then we got 93 cases,103 cases and 289 cases confirmed diagnosed and collect their clinical data to do retrospective analysis.Results:1. The whole situation of all admitted cases in group pre-intervention, transition and post-intervention:(1) The premature bloodstream infection’s admitted rates in our hospital of three groups (0.66%,1.38%,2.13%) are gradually raised (P<0.001). (2) The hospital infection incidence of premature bloodstream infections of three groups (0.13%,0.43%,0.54%) are gradually raised(P<0.001). (3) The antibacterial agents use intensity of three groups (11.94,10.05,8.43) gradually lowered, with the change of-29.40%.2.The comparison of premature bloodstream infections among gro up pre-intervention, transition and post-intervention:(1) Clinical features:the comparison about the utilization rates o-f total parenteral nutrition (74.19%,88.35%,86.85%), fat emulsion(70. 97%,83.00%,85.47%), PICC(7.53%,15.53%,21.80%), mechanical ve ntilation(26,88%,32.04%,41.18%) and phototherapy(58.06%,65.05%, 75.78%) shows group post-intervention is higher than pre-interventio n(P<0.05). (2) Pathogenic species:three groups’ Gram positive bacteri a detection rates (56.67%,29.17%,33.33%) has decreased (P<0.05). (3) There is no significant differences in antibacterial agent resistance s of the common pathogenic bacteria and fungus among three groups (P>0.05). (4) The antibacterial agent single usage rates of three grou ps(8.6%,33.01%,53.65%) are gradually raised(P<0.001), while the d uplex use rates (77.42%,56.31%,42.51%) and triple use rates (13.9 8%,10.68%,3.83%) are gradually increased(P<0.001). (5) The chang e times of antibacterial agents among three groups ((1.58±1.37), (1.4 4±1.59), (1.19±1.09)) gradually lowered (P=0.021). (6) There is no significant differences of the special antibacterial agent usage rates, th e average days antibacterial agents used, the outcome or the average hospitalized days of three groups (P>0.05).Conclusion:With antibacterial agents’ special intervention, the antibacterial agents use intensity of three groups gradually lowered and the change times or the combined usage of antibacterial agents for premature bloodstream infections have been improved significantly, meanwhile, it did not increase the hospitalized days or change the outcome for premature bloodstream infections. That prompts the special intervention of antibacterial agents’ clinical application for premature bloodstream infections has feasibility and availability.