Efficacy And Prognosis Evaluation Of Surgical Resection For Patients With Colorectal Liver Metastases

Objetive:Exploring the influence on the prognosis of surgical treatment and the prognostic factors on patientssuffering from colorectal liver metastases. Methods: A retrospective analysis of clinical and prognostic data of 82 cases patients suffer fromcolorectal liver metastasesin Zhongshan Hospital of Xiamen University, between January 2008-2014 January,Of which 49 cases underwent surgery,33 cases did not undergo surgery. The log-Rank, Kaplan-Meier method and Cox proportional hazards regression model were used to analyze survival rate, survival curves plottedand multivariate,respectively. P <0.05 means significant difference.Results:The survival rates of 1 year after surgery, the 3-year and 5-yearwere 85.7%, 51.0% and 22.4% in 49 cases with colorectal cancer liver metastases and primary tumor resection patients.of which the incidence of complications was 12.2 %,perioperative mortality rate was 0.0%, andthe median survival was 37 months. 33 patients treated without surgery, 1 year, 2 years, 3-year survival rates were 69.7%, 21.2%, 0.0%, and the median survival time was 18 months. Univariate analysis showed that the TN staging, the degree of differentiation of the primary tumor,the number and size of liver metastases were related with overall survival time of patients(P <0.05), but no with the patient’s age, sex, preoperative CEA levels, the site of the primary tumor and liver metastases distribution(P> 0.05). Multivariate analysis found that the TN staging of the primary tumor and the number of liver metastases is an independent risk factor for overall survival of patients with surgical treatment. Conclusion:Surgical resection of the primary tumor and liver metastases can improve the prognosisof patients with colorectal liver metastases.It can significantly improve survival rate ofpatients.Include the TN staging,differentiation,the number and size of liver metastasesare all the prognostic factors for the primary tumor. The fewer the number of liver metastases and earliertumor TN stage, the better prognosis.