Prognostic Analysis Of Non-small Cell Lung Cancer Patients Receiving Intensity-modulated Radiation Therapy

[Objective] To analyze the survival of non-small cell lung cancer patients receiving intensity modulated radiation therapy and investigate the related prognostic factors.?Methods?A retrospective data of non small cell lung cancer patients receiving first intensity modulated radiation therapy(IMRT) from June 2009 to November 2014 in radiation oncology department at the First Affiliated Hospital of Fujian Medical University.The patients ’data including age 、gender、tumor pathology、with or without chemotherapy 、with or without induction chemotherapy、with or without additional chemotherapy、tumor location、tumor volume before radiotherapy 、radiation dose of the primary tumor、volume reduction rate、the classification of radiation pneumonitis. The one-year、two-year and three-year overall time(OS) were calculated. Every group of median survival time(MST) also included. Kaplan-Meier analysis was used to calculate survival. Log-rank analysis was used to compare survival differences between different groups. The prognosis was analyzed by Cox multivariate model.[Results] 75 patients were adopted in this study and 70 patients had been followed up.The follow-up rate was 93.3%(70/75).The follow-up time was 1-60 months and the median follow-up time was 10 months. The median survival time was 20 months.The 1 year、2-and 3-year OS rate were 57.1%、39.6% and 22.4%,respectively. Univariate analysis show that group received chemotherapy was better than the group that only do the radiotherapy alone(P=0.015); the group of the ECOG score is 0 to 1 had better survival than the group that the ECOG score is 2(P=0.003). The patients with Stage I-III disease were associated with better survival, while the patients with stage IV disease were in poor survival. Combine with multivariate analysis, received chemotherapy、ECOG score、the radiation dose of tumor were all independent prognostic factor factors for overall survival in non-small cell lung cancer patients that received IMRT(P<0.05).[Conclusions]Compare with radiotherapy alone, patients who received the chemotherapy have better survival. ECOG score and radiation dose of primary tumor may become independent prognostic factors for survival of NSCLC patients receiving intensity-modulated radiation therapy.