Expression Of Aldehyde Dehydrogenase-1,Periostin In Invasive Endometrial Cancer And Its Clinical Significance

Objective: The purpose of this study is to investigate the expression of tumor stem cell marker aldehyde dehydrognase 1(ALDH1)、Periostin in endometrial cancer and its clinical significance.Methods:The expression of ALDH1 、Periostin protein was examined by immunohistochemical staining in 198 endometrial cancer tissues.The correlation analysis of patients was evaluated based on the clinicopathological characteristics.Results: The positive expression rate of ALDH-1 was 85.34%, of which low expression account for the majority(65.15%); ALDH-1 positive expression had a significant correlation with age,different histological grade, clinical stage,and ER/PR(-)(p<0.05), but had no significant correlation with lymph node metastasis,and vascular invasion(p>0.05). The positive expression rate of Periostin was 85.34%, of which low expression account for the majority(69.70%); Periostin positive expression had a significant correlation with different histological grade, clinical stage,lymph node metastasis,and ER/PR(+)(p<0.05), but had no significant correlation with patient age,and vascular invasion(p>0.05);ALDH-1,Periostin protein positive expression in patients with disease-free survival time less than ALDH-1,Periostin protein-negative patients(p<0.05).Conclusion: Majority of cervical carcinoma cells have ALDH-1 protein and Periostin protein expression, but ALDH-1、Periostin expression in tissues mainly with low expression(<30%), which match for the cancer stem cells in tumors account for a small part;ALDH-1、Periostin can be used as a specific marker of endometrial cancer stem cells to monitor the endometrial cancer progression, as an independent factor for predicting the prognosis of endometrial cancer.