The Study Of Correlation Among Distribution Of Body Fat,diabetes And Cardiovascular By Dual-energy X-ray Absorptiometry

Objective The content and distribution of human body fat were measured by the use of dual-energy X-ray absorptiometry(DEXA). Then, associations of human bo dy fat content with insulin resistance, islet beta cell function and metabolic dis orders were investigated. Meanwhile,compare with Body Mass Index(BMI)w hich association of islet beta cell function and cardiovascular disorder(CVD).Be sides, this study describes the relationship between distribution of body fat cont ent and both coronary and carotid arteries in order to unveiling correlations bet ween body fat content and cardiovascular diseases among subjects with or with out type 2 diabetes and put forward the basis of prediction on type 2 diabetes(T2DM) and CVD in clinical.Methods The clinical data and the results of investigation such as blood biochemical indicators, simple anthropometric parameters, DEXA, multi-slice spiral CT coronary angiography, and carotid ultrasonography were collected and recorded in patients with Type 2 diabetes mellitus(n=44)and non-diabetic patients(n=21).The diabetics were stratified and divided into two groups with either normal weight in DM or obesity in DM, according to Body Mass Index(BMI). Further analysis on the distribution of body fat content, and its correlation to type 2 diabetes and cardiovascular disease were implemented.Results1. Indicators such as systolic pressure, blood sugar and C peptide 2 hours after meal, hemoglobin A1 c, BMI, HOMA-β,coronary arterycalcium score and total body fat mass were significantly different between the diabetic group and the non-diabetic one(p < 0.05). 2. For the group of normal weight and the obese group, waist, systolic pressure, apolipoprotein B(Apo B), serum uric acid(UA), HOMA-β, carotid intima-media thickness, A, G fat content, content of muscles and A/G reveals statistically significant differences(p < 0.05). 3. The results of multiple regression equation analysis: HDL-C was the main influence factor of coronary artery calcium score for:(β=-32.95,p=0.00). The main influence factor for carotid intima-media thickness was A/G(β=-0.98,p=0.04). The main influence factor for HOMA-IR was BMI(β= 2.62, p= 0.00 and the main influence factor for HOMA-β was TC(β=-39.64,p=0.00).Conclusion The content and distribution of body fat have some effects on the function of islet cells, insulin resistance,cardiovascular diseases. However, dyslipidemia was a more profound risk factor compared to the content and distribution of body fat.