Evaluation Of Right Ventricular Pressure Load Effects On Left Ventricular Myocardial Mechanics By Speckle Tracking Technology

Objective:application spot tracking technology to evaluate right ventricular pressure load influence on left ventricular myocardial mechanics, the early detection of the change of left ventricular function in patients with pulmonary hypertension, provide the basis for early clinical intervention. Methods:In our hospital with pulmonary hypertension(PH) in 74 patients as the case group Inclusion criteria were transthoracic Doppler ultrasound PASP> 40 mm Hg, LVEF> 50%(according to PASP divided into mild, moderate and severe pulmonary hypertension, respectively In A, B, C group ID), the control group of age, 40 cases of healthy volunteers and sex-matched, underwent echocardiography. Conventional ultrasonic measuring cardiac parameters, biplane left ventricular ejection fraction was measured(LVEF), collecting and storing 3-5 cardiac cycles LV apical four-chamber, three-chamber, two-chamber and mitral level, papillary muscle apical the level of short-axis view of a moving image, the image is imported Qlab workstation line off-line analysis, measuring each segment peak systolic left ventricular longitudinal strain(LS), peak systolic radial strain(RS), peak systolic circumferential strain(CS) and calculated left ventricular systolic annular strain(GCS), the overall systolic radial strain(GRS), overall systolic longitudinal strain(GLS), free wall(LAT, sidewall + posterior wall) and interventricular septum(IVS, Anterior septum+After ventricular septal) Overall CS, RS, LS; measure the heart and cardiac apical rotation angle peak and peak time. Analyze and compare the measurement results of each group. Results:①LVEF: A, B, C group was significantly lower than the control group(p>0.05). ②GRSS, GCSS, GLSS: B, Group C lower than the control group and group A, group C than in group B(p<0.05). ③LAT and IVS overall LS, RS, CS: B, Group C lower than the control group and group A, group C than in group B(p<0.05). ④ ventricular apical segment and basal segment rotation angle: B, Group C lower than the control group and group A, group C than in group B(p<0.05). ⑤A group GRSS, GCSS, GLSS and LAT and IVS overall LS, RS, CS and normal control group was not statistically significant(p>0.05). ⑥A left ventricular basal segment rotation angle lower(p<0.05). Conclusion:①right ventricular pressure overload can lead to increased left ventricular mechanical damage, left ventricular strain may be earlier than the LVEF found changes in left ventricular function.②PH patients with pulmonary hypertension left ventricular strain gradually reduced.③LV basal segments rotation angle can be found in PH patients with mild left ventricular mechanics change, compared with other reference strain Several sensitive.