Clinical Observation Of Nanofat In Faciacial Non-structural Grafting

Objective:Part I, to assess the clinical effects of Nanofat in facial non-structural grafting.Part II, to establish an animal model for Nanofat in non-structural grafting.Methond:Part I from september 2014 to december 2014, 10 cases were enrolled for nanofat non-structural grafting. Nanofat was obtained mechanically, then injection was performed by 27-gauge needle until a yellowish discoloration of the skin showed up. The paitents were called back for photo and other treatment.Part II, Adipose tissue was harvested and cut into granules(AG) from the scapular or groin region of six healthy New Zealand rabbits. Nanofat was obtained mechanically, then implanted into the right ears of the rabbits as the experiment group. Pure AG transplantation in the left ears of the rabbits was used as the control. The blood vessels in the implants were observed by transmitting light. The survival rates of the implants were measured at 0, 1 and 3 months after surgery.Results:Part I, Effective for 9 cases, in which remarkable improvements in skin quality for 7 cases with skin ageing problem, no effective for 1 case. The clinical effects were stable for 7cases, reoperation for 3 cases in following up period. There’s no unwanted complications were observed.Part II, The animal model in rabbit ears for Nanofat non-structural transplant was easily observed and measured in vivo.Conclusion:Part I, Nanofat injection was benefit for Skin rejuvenationPart II, The Nanofat that lose fat cell activity, affected the survival rate of transplanted fat,but stimulated skin repair and regeneration. Nanofat grafting provides experimental evidence in the field of non-shaping.