Effect Of Interferon α2b On Amino Acid Concentration In Cerebrospinal Fluid Of Patients With Herpes Zoster

Objective:(1).To evaluate the effect of paraspinal nerve blocking with interferon α2b on amino acid concentration in cerebrospinal fluid of patients with herpes zoster;(2).To evaluate the effect of pain relief with acute herpes zoster after using paraspinal nerve blocking with interferon α2b effect;(3).To evaluate the preventive efficacy of postherpetic neuralgia after using paraspinal nerve blocking with interferon α2b effect.Methods:The 60 cases of herpes zoster were divided into interferon α-2b group(group A) and control group(group B) randomly and averagely.Both A and B groups are accepted drugs and paravertebral nerve block,the only difference between group A and B is whether to use the recombinant human interferon α-2b.For each patient,we measure the record VAS pain score at T0(before treatment)、T1(1 week after treatment)、T2(2 weeks after treatment)、T3(4 weeks after treatment).we measure the amounts of glutamic acid and γ-aminobutyric acid in cerebrospinal fluid at T0 、 T1 、 T3.Then we calculate the incidence of post herpetic neuralgia at T3(4 weeks after treatment)、T4(12 weeks after treatment).At last, the patients make self-evaluation about the efficacy and we statistical all the treatment times.Results:The difference of glutamic acid level、the γ-aminobutyric acid level and VAS painscore between two groups is not statistically significant(P>0.05).Compared with pretherapy, the levels of glutamic acid in both groups are decreased,the γ-aminobutyric acid level in both groups are increased at any time after treatment(P<0.05),in addition,there is an obvious difference between group A and group B.Compared with pretherapy,the VAS pain score in both groups are decreased at any time after treatment(P<0.05), in addition,there is an obvious difference between group A and group B. Compared with B group,the patients in group A have fewer therapy times( P<0.001) and feel better after treatment(P<0.05).The incidence of postherpetic neuralgia in group A is lower than that group B at T3、T4(P<0.05).All of patients have any redadverse reactions associated with recombinant human interferon α2b.Conclusion:Paraspinal nerve block with recombinant human interferon α2b can related to reduce the content of Glu,GABA levels in the cerebrospinal fluid increases,and treat herpes zoster patients effectively,also can availably prevent the postherpetic neuralgia.