Evaluation Parameters Of Functional Liver Reserve For Posthepatectomy Patients With Alveolar Echinococcosis

AIM: To investigate the influence of the size of standard remnant liver volume(SRLV),cholines terase(CHE), gamma-glutamyltransferase(GGT), liver cirrhosis(LC) and alkaline phosphate(ALP),on the liver functional reserve in patients with posthepatectomy for alveolar echinococcosis,and to assess the relationship between this factors and hepatic insufficiency.METHODS: Sixty patients with alveolar echinococcosis who underwent liver resection from March 2013 to March 2015 at People’s Hospital of Qinghai Province were included in the study. SRLV, GGT,CHE, LC and ALP were determined, and multivariate Logistic analysis was performed to detect their influence on the liver functional reserve. Using ROC curve analysis, it is concluded that predictive value for hepatic insufficiency of liver reserve function and the critical value,then calculate the critical value results in the incidence of liver insufficiency.RESULTS: LC, size of total liver volume(TLV), and GGT had a significant effect on liver functional reserve preoperatively(OR= 2.484, 0.2796, and 1.0000, respectively). LC,SRLV and GGT had a significant effect on the liver functional reserve postoperatively(OR =6.78480, 1.00002, and 1.00031, respectively). The influence of CHE and ALP on liver functional reserve could not be determined.Surgery also had an impact on the reserve function of the liver. The prediction critical values of SRLV for preoperative hepatic insufficiency are 498.50 ml/m2, The prediction critical values of GGT for preoperative hepatic insufficiency are 97.5 U/L. When the SRLV <498.50 ml / m2, the hepatic insufficiency was 50%, when GGT> 97.5U / L, the incidence of liver insufficiency was 45.5%. The influence of CHE and ALP on liver functional reserve could not be determined.Surgery also had an impact on the reserve function of the liver.CONCLUSION: LC, SRLV, and GGT have an effect on the liver reserve function in patients with alveolar echinococcosis. Postoperative liver reserve function declines significantly after surgery, and the influencing factors include LC,SRLV, and GGT.