Pharmaceutical Research Of Ginseng Notoginseng Sanjie Detoxification Capsule

Ginseng notoginseng Sanjie detoxification capsules is combined with the implementation research of the formulation developed in our laboratory and Wuhan Cod Chinese Medicine Hospital,is a clinical applications clinical secret recipe for many years by De-Zhong Zhang.By Panax quinquefolius,Notoginseng,Radix Glycyrrhizae,such as the composition of 10 herbs,which can be used for prescriptions energy of life,but also can be used for blood circulation and has the role of detoxification,but also to have better analgesic effect.The clinical experience for the treatment of tumor diseases for decades,can improve the symptoms, control of tumor development,relieve the pain of patients, improve the quality of life,welcomed by the majority of patients.On the basis of clinical efficacy,proposed to the development of hospital preparations.This dissertation has conducted the research of Ginseng notoginseng Sanjie detoxification capsule pharmaceutical and acute toxicity test.By studying the orthogonal experiment and single factor combination of modern preparation techniques,ginseng notoginseng sanjie detoxification capsules extraction process and preparations molding process has been systematically studied to obtain a reliable technical parameters,carried out the test certificate can transition to industrial production.The preparation process for the final prescription proportion water extraction of eight Chinese herbal medicines of Radix Paeoniae Alba,Fructus aurantii,Radix Glycyrrhizae,adding 12 times amount of water soaking moistening,plus twelve times the amount of water to soak for half an hour,extracting 3 times,the first time 2h,second 1.5h,third 1h,filtration,filtrateis concentrated to the relative density of 1.35-1.55(60℃),and the amount of starch mixed,vacuum drying(60℃) to dry powder.The prescription ratio of Panax qinquefolius,Notoginseng,60℃ vacuum drying box drying 5~6h after the release of cold crushing,80 mesh sieve,have drug powder.Take the proportion of Panax ginseng and notoginseng prescription medicines,into 60℃ oven bake 5~6h decompression, after the fifth over and let cool a powder sieve to obtain crude drugs original powder.Dry cream powder and powder raw mix, according to the proportion of added starch,with 80% ethanol made of soft material,pelletizing,drying at 60℃,whole grain,filling, polypropylene bottles, and aluminum foil sealing,have ginseng notoginseng sanjie detoxification capsules,0.45 g each piece.By using modern analysis method,systematically investigate the ginseng notoginseng sanjie detoxification capsules traits, TLC,various effective ingredients content,moisture, Disintegration,and heavy metals,arsenic salt,microbial limit examination and develop the hospital preparation perfect quality standard,can effectively control the inner quality of ginseng notoginseng sanjie detoxification capsules.Under the quality standard of TLC items for Panax ginseng,Notoginseng,Radix Paeoniae Alba,Fructus aurantii,Radix Glycyrrhizae qualitative identification.Study on content determination,and established the standard of saponins of Panax quinquefolium and Notoginseng.According to "Chinese medicine,natural medicine research on the stability of technical guidelines",on the basis of participate in quality standard of ginseng notoginseng sanjie detoxification capsules for the detection of methods.The test method is used by the acceleration and room temperature test,to study for a period of twelve months of its initial stability.There were no significant changes in the investigation index,showed ginseng notoginseng Sanjie detoxification capsules stable quality inspection period,which provided the basis for its clinical use.Referring to the development of new varieties of traditional Chinese medicine literature related toxicity tests to study the participation of ginseng notoginseng Sanjie detoxification capsules acute toxicity.The results show that the maximum tolerated dose of ginseng notoginseng Sanjie detoxification capsules one-time intragastric administration in mice was 60 g per kg.And the daily dosage prescribed in draft quality compared to standard clinical adult daily dosage equivalent to 240 times.The results indicate that the agent on service delivery is safe and reliable.