| Background and Objective:Chronic allograft nephropathy(CAN) is the leading cause of late graft loss of function, are important factors affecting long-term survival of the transplanted kidney, overcome CAN is a worldwide problem. Currently CAN control measures mainly to adjust immunosuppressants, lipid-lowering, blood pressure, etc., but the effect is not ideal. Only through different mechanisms of action of drugs joint intervention to achieve synergies prevention of CAN. Based on this, the subject application of traditional Chinese medicine Centella asiatica combined with immunosuppressive therapy Centella CAN, evaluate Centella asiatica particles joint immunosuppressive regimen CAN comprehensive efficacy and safety, aims to further standardize and optimize CAN Integrative prevention strategy, to provide a relatively scientific and practical ways and means of treatment, the formation of a low cost have Chinese characteristics, safe, effective and easy to grasp optimized treatment.Methods: patients of outpatient and inpatient diagnosis of chronic allograft nephropathy in Urology Renal Transplant Unit in the First Affiliated Hospital of Henan College of Traditional Chinese Medicine, as research subjects, according to the inclusion and exclusion criteria for selection of cases, by stratified randomly divided into the treatment group and control group, both groups CNI-based regimen(Cs A / FK506 + MMF + Pred triple immunosuppressive regimen) to maintain the routine treatment, The treatment group took Centella asiatica particles(30g/d, blunt), in addition to conventional therapy control group without Centella asiatica particles particles, respectively before treatment, the determination of 1,3,6 months after treatment, when two cases of patients with laboratory parameters were observed in patients with blood, liver function(ALT, AST), renal function(BUN, Scr), blood lipids(TC, TG), blood sugar, blood β2- microglobulin(β2-MG), T lymphocyte subsets(relative + absolute), urinary NAG, 24-hour urine protein, creatinine clearance(Ccr), T cell subsets(relative + absolute), etc; and before treatment and at 6 months after treatment, did renal ultrasonography and renal biopsy. The Statistics of two groups were done.Results:When the group of sex, age, duration and the indicators studied two groups before treatment had no significant difference and statistically significant(P>0.05), the two groups were comparable.Comparison of two groups, the total efficiency of the treatment group, significant efficiency; the total efficiency is 72.5%,the control group is 55.2%, which was efficient, there was statistically significant(P <0 05).Centella asiatica group after treatment, BUN, Scr, Ccr, serum β2-MG, urinary NAG, 24-hour urine protein, T lymphocyte subsets(relative + absolute),PLT before treatment were significantly different, there are statistics significance(P<0.05), Comparing the treatment group and the control group, a significant difference was statistically significant(P<0.05).Liver function(ALT, AST), lipids(TC, TG), blood sugar and other indicators of the two groups were not significantly different before and after treatment, no significant(P>0.05), Comparing the treatment group and the control group no significant difference was not statistically significant(P>0.05).The treatment group were significantly different before and three months after treatment, there was statistically significant(P<0.05),Between the treatment group and the control group, a significant difference was statistically significant(P<0.05).The pathological changes of kidney transplantation after three months of treatment compared with before treatment in the treatment group,significant difference was statistically significant(P<0.05),comparing the treatment group and the control group, a significant difference was statistically significant(P<0.05).Conclusion:Centella asiatica joint immunosuppressive drugs can improve renal function and reduce urinary protein particles. Centella asiatica joint immunosuppressive drugs have a moderating role in the body’s immune status.Centella asiatica particles can improve renal blood circulation, increase blood flow, reduce vascular resistance index.Centella asiatica particles can reduce tubulointerstitialdamageagainst renal interstitial fibrosis, is a useful supplement CAN variety of treatment programs, and no significant adverse events, security is good. |
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