The Correlation Between The Changes Of Oxidative Stress And The SICAM-1 Level And The Adverse Pregnancy Outcome In Patients With Gestational Diabetes Mellitus

Objective : To investigate the changes of oxidative stress markers MDA and SOD, and vascular disease markers sICAM-1 in patients with gestational diabetes mellitus. To analyze the relationship between oxidative stress and vascular disease, and the adverse pregnancy outcomes in patients with gestational diabetes mellitus.Methods: Selecting 30 healthy pregnant women and 60 gestational diabetes mellitus(GDM) who have delivered in our hospital,and respectively as the experimental group and the contrast group. According to blood glucose controlled well, the experimental group is divided into the control dissatisfaction group and satisfaction one. Determinating the three groups’ lipid peroxides MDA, superoxide dismutase SOD and soluble intercellular adhesion molecule-1(sICAM-1) levels of venous blood of pregnant women and umbilical cord, and make a statistical analysis. At the same time, three groups of pregnant women placental tissue are made for a pathological detection examination. Comparing the incidence rates of maternal and fetal adverse outcomes in the three groups. To further analyze the relationship between oxidative stress markers and vascular disease markers, and adverse pregnancy outcomes in patients with gestational diabetes mellitusResult:1.Lipid oxidation MDA’ level of gestational diabetes mellitus group in venous blood of pregnant women and umbilical cord were significantly higher than that of normal group(P maternal blood = 0.015, P maternal blood = 0.000, P umbilical cord blood = 0.001, P umbilical cord blood= 0.010, P < 0.05).However, superoxide dismutase SOD’ level of gestational diabetes mellitus in venous blood of pregnant women and umbilical cord were significantly lower than that of normal group(P maternal blood = 0.047, P maternal blood = 0.003, P umbilical cord blood = 0.002, P umbilical cord blood = 0.015, P < 0.05),the distinctions were outstanding.2. Vascular disease markers sICAM- 1’ levels of gestational diabetes mellitus in venous blood of pregnant women and umbilical cord were significantly higher than those in normal group(P maternal blood = 0.015, P maternal blood = 0.010, P umbilical cord blood = 0.000, P umbilical cord blood = 0.023, P < 0.05), the distinctions were outstanding.3. The group of blood glucose control was not satisfied in gestational diabetes mellitus was compared with the control satisfied group and the normal group, the proportion of the placental villus maturation, the thickening of the major villus small artery and villus capillary expansion was increased obviously(P < 0.05),the distinctions were outstanding. There was no outstanding distinction between the control satisfied group and the normal women(P > 0.05), the distinctions were not outstanding.4.The incidence rates of maternal adverse outcomes in gestational diabetes mellitus during the glucose control dissatisfied group were significantly higher than that of the control satisfied group and the normal women(P<0.05), the distinctions were outstanding. There was no significant difference between the control satisfied group and the normal pregnant women(P>0.05).5. Gestational diabetes mellitus pregnant women with adverse pregnancy outcome group’s lipid peroxide MDA was significantly higher than that of normal pregnancy group(P = 0.018,P=0.010, P < 0.05). Superoxide dismutase(SOD) was significantly lower than that of normal pregnancy group(P = 0.003, P = 0.008, P < 0.05).The distinctions were outstanding.6. Gestational diabetes mellitus pregnant women with adverse pregnancy outcome group’s sICAM-1 was significantly higher than that of normal pregnancy group(P=0.025, P=0.040, P < 0.05). The distinctions were outstanding.Conclusion:1. The reactive oxygen species increased and levels of antioxidants lowed in pregnant women with gestational diabetes mellitus. Oxidative capacity was more than antioxidant capacity, developing the oxidative stress. The degree of oxidative stress was positively related to the incidence of adverse outcomes.2. The level of sICAM-1 increased significantly in pregnant women with gestational diabetes mellitus,indicating that sICAM-1 involved in the occurrence of gestational diabetes mellitus. There are different degrees of vascular disease in the pregnant women with gestational diabetes mellitus.The level of vascular disease was positively related to the incidence of adverse outcomes.3. To understand the pathogenesis of gestational diabetes mellitus and its complications, and provide a new research angle and method for the treatment of gestational diabetes mellitus and its complications..