| Objective: By observing the high-risk stroke population with advanced perio dontitis patients before and after periodontal non-surgical treatment of serum solu ble CD40 ligand(sCD40L) and homocysteine,(HCY) levels of change, to discuss the relationship and mutual influence of advanced periodontitis and high-risk str oke population and periodontal non-surgical treatment to the development of stro ke in stroke prevention in this high-risk population effect.Methods: Collection 76 the high-risk population of stroke with the advanced periodontitis patients, were randomly divided into two groups: There are 40 pati ents in the group A receiving routine medical maintenance therapy and periodont al non-surgical treatment. The other 36 patients as the group B, only accept the corresponding conventional maintenance therapy. At the same time, 36 chronic pe riodontal patients without the high-risk population of stroke were collected as the group C who were received periodontal non-surgical treatment. The age of all t he patients between 40 to 75 years old.All the patients were inspected the following: general information enrolled i n age, sex, drinking alcohol, height,weight. And periodontal examination indexes including Plaque index(PLI), Bleeding on probing(BOP), periodontal Probing depth(PD), Attachment loss(AL), all operations are performed by the same oralmedical professional.Detection of serum soluble CD40 ligand and homocysteine levels respective ly with Enzyme linked immunosorbent assay(ELISA) method and chemiluminesc ence method.Three months after the treatment, we will review the level of various indexe s of the three groups, and observe the incidence rate of stroke in the group A a nd group B. The data was analyzed using SPSS17.0 software carries on statistic analysis.Results: There was no significant difference between sex, age, drinking, etc.in group A and C(P > 0.05), the patients with advanced periodontitis and th e high-risk population of stroke exhibited higher levels of sCD40 L and HCY, ble eding on probing(BOP), probing depths(PD), Plaque index(PLI)when compare d to group C(P<0.05). The indexes had no difference between the group A an d group B(P > 0.05).After three month of therapy, the group A exhibited significantly lower levels of the various indices except HCY when compared to group B, there are significant differences(P<0.05). The difference of periodontal index PLI, BOP and AL was not statistically significant(P>0.05), levels of serum sCD40 L and HCY, PD are higher than the groups C, there are significant differences(P<0.05).The group A and group C before and after treatment by itself comparison: the level of sCD40 L, HCY, PD, AL and BOP were decreased, there was significant difference(P<0.01), the level of PLI was no significant difference(P>0.05).Observation on stroke incidence of periodontal basic treatment after 3 month s: group A did not happen, group B had 3 people, but the difference was not st atistically significant(P>0.05).Correlation analysis of each index in patients with advanced periodontitis :W e also observed the levels of sCD40 L is positively related with PD and HCY; th e levels of HCY and BOP, PD, PLI also present positive correlation.Conclusion:1. The periodontal lesion extent in the patients with the advanced periodonti tis and high-risk stroke populations is higher than that of advanced periodontal p atients.2. Periodontitis patients of sCD40 L and HCY in serum may be jointly play a role in the occurrence and development of chronic periodontitis.3. Periodontal treatment improves the body’s inflammatory state in the patient s with the advanced periodontitis and high-risk stroke populations, and to a certa in extent, periodontal treatment may reduce the risk of the high-risk stroke popula tion to the development of stroke. |
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