Influence Factors Of Term Neonates Blood Glucose In Pregnancy With Gestational Diabetes Mellitus

Background and objective:The morbidity of gestational diabetes mellitus (GDM) in China is higher in recent years. The newborn is easily to have hypoglycaemia because of the glycometabolism disorder of GDM in pregnancy term, which will lead to injury of nervous system; mental and developmental retardation and even result in perinatal mortality of newborn. The study of GDM now is focus on epidemiology of hypoglycaemia in newborn; glucose control of GDM parturient; glucose monitoring of perinatal and prevention of hypoglycaemia of newborn. But there are several controversy problems now as follows: what’s the discipline and influence factor of newborn hypoglysaemia? How to choose the proper delivery and feeding mode? Therefore, this study is focus on the delivery mode, cleanliness of amniotic fluid,24hours breast milk, feeding mode, the discipline of term neonate glucose and influence factors by GDM parturient. From this study, we hope to raise more attention to hypoglycaemia of newborn in clinical experience. And to investigate the safety of normal delivery and breast-feeding in newborn by GDM parturient to prevent hypopglycaemia. Meanwhile, by investigate the influence factor of hypoglycaemia of newborn to find the discipline of glucose of newborn by GDM parturient. We also hope to find the reason of transfer to NICU of newborn because of hypoglycaemia. And to provide theoretical basis for controlling the hypoglycaemia of newborn in clinical experience.Methods:229cases of GDM from July2013to December2013were enrolled into this study. The glucose of neonatal were tested at1,3,6,12,24hours and recorded. The influence factors such as delivery mode, gestational weeks, amniotic fluid cleanliness, the maternal milk in24hours, the breast feeding or not and bodyweight of newborn were investigated. Box diagram and quartilies were use to induct the data. The diagnosed method was done by IADPSG guideline. The influence reason of neonatal glucose was systematic analyzed by logarithmic transformation of non-normal distribution, fitting mixed effects model for longitudinal data and logistic regression analysis. R3.1statistics soft was used for this study. Then the mathematical model of glucose influence factor was established and logistic analyze, ANOVA were used in this article. Size of test a=0.05, and p<0.05were considered as significant difference.Results:There was no significant difference of glucose level in term neonatal by gestational weeks, amniotic fluid cleanliness, amniotic fluid cleanliness, and the maternal milk in24hours. The neonatal weight is a important influence factor to transfer to NICU because of hypoglucemia. The probability of hypoglyceamia will be2.89fold higher if the bodyweight gain1kg. The probability of hypoglyceamia is not increased in term neonatal of GDM who get breastfeeding with normal bodyweight under the monitoring blood glucose.Conclusion:This study concluded that, the bodyweight is the main influence factor that caused hypoglycemia and then lead to transfer to NICU. The probability of hypoglyceamia is2.89fold higher if the bodyweight increased lkg. The breastfeeding to GDM neonatal is feasible if monitoring blood glucose frequently. Although there were several factors may influence the glucose level of neonatal, the delivery mode, amniotic fluid cleanliness, the maternal milk in24hours has no influence to glucose of neonatal.