Multiple Endocrine Neoplasia Type2A:Report Of Three Cases

ObjectiveTo summary3cases and to review the literature of Multiple endocrine neoplasia type2A to discuss the pathogenesis, clinical manifestations, diagnosis and treatment in order to have patients of such disease diagnosed and treated earlier in the future.MethodsClinical datas of3cases of Multiple endocrine neoplasia admitted in the1st affiliated hospital of Medical College, Zhejiang University among2012-2014were analyzed retrospectively.ResultsThree patients all had obvious clinical manifestation mainly owing to increased catecholamine such as paroxysmal hypertension, heart palpitations, sweating, dizziness, headache, nausea, vomiting and tremor. They all had adrenal pheochromocytoma, different levels of thyroid abnormalities, no parathyroid hyperplasis or adenoma, and diagnosed as MEN2A by biochemical tests, imaging and pathological examination. They were treated by surgery, and one patient had recurrence of thyroid carcinoma and pheochromocytoma.ConclusionsPatients with tumors in more than one endocrine gland like thyroid, adrenal and parathyroid should be considered such disease, RET genetic testing is the gold standard for diagnosis of this disease, biochemical tests and imaging detection are common ways to help diagnosis in clinic when genetic testing is not available. Surgical excision is the predominant way to treat MEN2A, early diagnosis and treatment are very important for patients.