| Alopecia areata is relatively common mental related diseases in Department of Dermatology. Due to alopecia areata occurs in the head and other exposed parts, seriously affecting the appearance of the image of the patient’s social and employment,bring great psychological burden and mental stress to patients, can lead to depression,anxiety and other mood disorders occur, in which depression is more common. Serious mental burden will increase the alopecia areata, reduce the therapeutic effect, creating a vicious cycle, so the psychological treatment is very important.The five-elements music of TCM therapy is the yin and yang in Chinese traditional medicine, the theoretical unity of Heaven, Earth, and modern music therapy theory combines innovative psychotherapy, not only can improve the symptoms of the disease itself,but also adjust the mental state,and Jane,efficiency, convenient, low- cost. In addition,some hospitals abroad with the effects of music therapy for the treatment of hair loss significantly, but is no domestic report, the research has not only the meaning of break- through in treatment of alopecia areata,also has the certain innovation,can also provide a new way of thinking and direction for the optimization of treatment plan.Objective To investigate the alopecia areata TCM five elements music therapy on liver qi stagnation type from the experimental study and clinical study(alopecia areata patients with depression) role; to explore the mechanisms of music therapy for alopecia areata and depression from the aspects of theory.This topic is divided into experimental study,clinical research and the theory research part. The specific methods with results, conclusions are as follows.1.The experimental study:Methods ①In C57 BL / 6 female mice as the research object, and alopecia areata depression composite model is set up, using multiple composite chronic stress(stimulation of moderate intensity chronic unpredictable) cause depression model model mice, consumption test and open field experiments with sugar(open-field) to determine the success of modeling. Model of depression after the success of modeling using rosin extension model establishment of alopecia areata wax epilation method,each animal for spine line left and right sides is symmetrical,mark the two pieces of the same size of lesion area(on the left side of the record for L, the right to R),with the extension of rosin wax epilation method to pull hair,remaining a don’t hair removal with tweezers,area of each lesion was about 1cm*2cm. ②The model animal were randomly divided into music group and control group,the daily 9:00-11:00,17:00-19:00,music group listen to the music group of the Chinese Medical Association of audio and video publishing house of the "the five elements" China traditional music(Angle and feather in positive mode),the control group did not listen.Eachanimal was left her lesions L with 2% minoxidil solution local daub,l,0.3ml/only,the right R water local daub,0.3ml/only. ③weekly weigh ins and weight changes,observe and record the growth, the lesions of skin and hair color change, and hair growth,open field experiment on the ninth day,music 17 days after treatment(open-field) to observe the change of depression, on the seventeenth day after treatment, to be put to death in mice, making the pathological slice, observe the hair growth.Results Music therapy for 9 days,17 days,two group than before treatment in open field were increased(P<0.05),and the music group than in the control group increased obviously(P<0.05).The music group L, control group L and control group R comparison,in growing period of time should be short(P<0.05), growth period prolonged(P<0.05),the number ofhair follicles increased(P<0.05);music group R and control group R,enter the period of growth time,growth period of time has no obvious difference,a hair follicle a few more(P<0.05).Conclusions music therapy can obviously relieve depression. Music + 2% minoxidil, 2% minoxidil, music therapy has effect on alopecia areata, curative effect is decreasing.The music alone can not make the hair in the growing period by the stationary phase in advance, nor can extend the hair growing period, but cooperate minoxidil can,that music can improve the curative effect of minoxidil for alopecia areata.2.The clinical study:Methods Seventy-eight Alopecia areata patients Complicated with depression were recruited and divided randomly music group(40 cases) and control group(38cases).Patients in the music group group listened the TCM five element music and Conventional treatment And patients in the control group just conventional treatment. Before treatment,After 1 course and 2 course of treatment, Hamilton Depression Scale(HDMA), the lesion score were used to investigate the patients respectively.Results Cooperation of music group total effectiveness was 95.0%, pure control group total effectiveness 57.6%. The result showed that there were significant differences between the scores of patients before and after the therapy in the two groups.Conclusions TCM five element music therapy has positive effect on helping relieve depression in patients with alopecia areata, shorten the onset time and enhance the curative effect. 3.The other part is the theory research:Methods ①Understanding of the pathogenesis of alopecia areata:traditional Chinese medicine TCM basic pathogenesis is deficiency of liver and kidney, Jing Xue deficiency. Western medicine pathogenesis is unclear,associated with genetic, immune,mental factors,this paper,especially in detail,discusses the effects of stress,psychological factors on the onset, progression, treatment of alopecia areata and its mechanism of action, and to explore its genetics and immunology mechanism will help to probe into music therapy for alopecia areata and depression mechanism. ②Introduction overview of music therapy and TCM five elements music therapy: mainly includes the effect and the mechanism of action of music therapy.Results and conclusions TCM five elements music for alopecia areata and depression effects could be achieved bythe HPA axis activity. |
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