Research On The Improvement Of Ginkgo Biloba Drops To Coronary Heart Disease Angina Pectoris With Left Ventricular Diastolic Dysfunction

Objective:Guided by the basic theory of TCM, according to the international society for heart disease and association and the world health organization task force on standardization of clinical nomenclature report the nomenclature and criteria for diagnosis of ischemic heart disease and 1979 Shanghai national traditional Chinese and western medicine combined with prevention and treatment of coronary heart disease, angina pectoris, arrhythmia research symposium revision of the "standard of coronary heart disease diagnosis reference", "Chinese traditional medicine new drug clinical research guiding principle" and so on related regulations as the basis,The ginkgo leaf drops of coronary heart disease angina pectoris with improvement of left ventricular diastolic dysfunction, from two aspects of long-term effects and instant effect, observe the treatment of angina pectoris and decreased left ventricular diastolic function improvement, explore its action mechanism, to explore the clinical treatment of coronary heart disease, left ventricular diastolic dysfunction new method, for coronary heart disease angina pectoris with left ventricular diastolic function provide possible and feasible treatment method.Method:All patients were from shandong university of Chinese medicine affiliated hospital of cardiology ward and outpatient extraction of patient of 60 cases of eligible for screening, randomly divided into two groups, the experimental group 30 cases and control group 30 cases.Control group: conventional treatment: thanks to aspirin, 0.1, 1 times a day;Times it grams, 12.5 mg, twice a day;Isosorbide dinitrate, 10 mg, three times a day.Treatment group: on the basis of above regular treatment, at the same time give a drop of ginkgo biloba, drip into the mouth of a 2 ml, 3 times a day.Treatment: 4 weeks.Safety indicators: 1) the general physical examination project: pulse, respiration, blood pressure, heart rate, heart rate, etc.2) blood, urine, stool routine(test before and after each inspection) at a time.3) liver(ALT, AST), kidney(BUN, Cr)(once the inspection before and after the test).Efficacy indicators 1) traditional Chinese medicine clinical symptoms, tongue and pulse condition, nitroglycerin stopped reduction rate, etc., were observed before and after the test record.2) ecg examination: the check once before and after the treatment.3) blood NT- proBNP check each time before and after treatment.4) echocardiography: peak E and E/A ratio, E/E ’ratio, and the check once before and after the treatment.Using spss19.0 statistical analysis software for data analysis, statistical conclusion, analysis of ginkgo biloba drops of coronary heart disease angina pectoris with left ventricular diastolic dysfunction is effective treatment effect.Result:This topic altogether collected 60 cases, studies show that 1) in the experimental group and control group patients gender, age, blood routine, urine routine, hepatic function, renal function, body mass index(bmi) and heart rate, body weight, body mass index, such as the experiment on relevant indicators were no statistical difference(P > 0.05), 2) before the treatment, the experimental group and treatment group in echocardiography in patients with related indicators E peak, EF, E/A, E/E ’and blood BNP values no statistical difference(P > 0.05), and 3) the experimental group before and after treatment, E peak, EF, E/A, E/E’ and blood BNP values were obviously improved, significant difference, statistically significant(P < 0.01), the control group before and after treatment although have mild improvement, but there was no significant difference(P > 0.05).4) the experimental group curative effect of traditional Chinese medicine indicators have improved significantly in before and after treatment, the significant difference, statistically significant(P < 0.01), the control group before and after treatment has improved significantly, there were significant differences(P < 0.01)Conclusion: In coronary heart disease angina pectoris with the treatment of left ventricular diastolic dysfunction add ginkgo biloba drops while on the general symptoms and not significantly better than that of conventional treatment, but it can effectively from the ultrasonic level significantly improve cardiac function, reduce myocardial damage, for coronary heart disease angina pectoris with left ventricular diastolic dysfunction are not advised, offers good prospects and direction.