Non-small Cell Lung Cancer Blood Stasis Clinical Observation And Experimental Study Of Lung Tumor Inhibition Treatment Cream

Objective: This study is a combination of mouse tumor model by establishing a Lewis lung carcinoma syndrome, lung tumor inhibition was observed intervention cream line non-small cell lung cancer blood stasis model; while 50 patients with advanced lung cancer in non-small cell clinical observation chemotherapy group differences in lung tumor inhibition with chemotherapy plus cream group at the macro and micro indicators characterization.Methods: Experimental study of some animals, the use of C57 BL / 6 mice, the establishment of gentleness and stagnation quality mouse model of macroeconomic and microeconomic indicators characterizing mice plasma fibrinogen(Fib), D-dimer(D-dimer), norepinephrine(NE), dopamine(DA), 5- hydroxytryptamine(5- HT) were measured to assess the quality of the established mouse stagnation reliability and stability. 2. The quality of gentleness and stagnation in mice inoculated with Lewis lung carcinoma cells, in the first five days after inoculation, grouped as the control group and the group of lung tumor inhibition cream. Were observed in mice inoculated with Lewis lung carcinoma cells after changes in tumor volume, tumor growth rate, lung metastasis rate and serum VEGF-C level. 3. The observed 50 cases of lung cancer patients with chemotherapy alone in advanced non-small cell with chemotherapy plus Chinese medicine group before and after treatment at the macro and micro indicators characterizing differences, for the clinical use of traditional Chinese medicine to provide a scientific basis.Results: 1. Quality mice show stagnation stagnation constitution after physical model, body weight decreased significantly compared with the gentleness of mice, and the significant(P <0.05). Serum Fib, D-dimer, NE, DA content increased significantly compared to mice with the gentleness group significantly decreased 5-HT content than gentleness compared and have significance(P <0.05). 2. stagnation quality control(QD) compared with the control group gentleness(PD) Lewis mice xenograft tumor volume growth, tumor weight, tumor growth rate, lung metastasis, tumor tissue VEGF-C mean optical density were different(P <0.05). Description Lewis mice stagnation quality group than gentleness group of lung cancer more growth and metastasis. 3. lung tumor inhibition cream treatment group(group gentleness and stagnation group) can be different degrees of inhibition of lung metastasis of Lewis lung carcinoma. Gentleness group, the rate of lung metastasis suppressor stagnation quality group was respectively35.21%、46.03%,one-way ANOVA analysis showed that each lung tumor inhibition cream group were lower than the corresponding control group, the difference was significant(P <0.05). 4. The lung tumor inhibition cream given medication group could inhibit the expression of different degrees of VEGF-C. Gentleness group, VEGF-C mean optical density of blood stasis group was(0.131±0.034)、(0.132±0.029), one-way ANOVA analysis showed that each lung tumor inhibition cream group were lower than the corresponding control groups with a significant(P <0.05). 5. Non-small cell lung cancer patients with blood stasis symptom ratings of the amount of assessment scores before and after treatment with chemotherapy, no improvement of symptoms is determined before and after treatment with chemotherapy plus Chinese medicine group determination partial improvement of symptoms; KPS score in the chemotherapy group and chemotherapy medicine after treatment than before treatment group scores were increased(P <0.05), and the chemotherapy group than in the chemotherapy group medicine physical condition much improved, KPS score increased more,(P <0.05); changes in terms of focus, the two groups were compared before and after treatment significantly reduced lesion area where chemotherapy group compared with chemotherapy alone medicine lesion size reduction is more significant, statistically significant,(P <0.05).Conclusions: 1. Using established subcutaneous epinephrine plus tied method is different from the gentleness stagnation quality mouse mouse, an animal model in order to establish meaningful qualitative stagnation. 2. The quality of mouse Lewis stasis group than gentleness group of lung cancer more growth and metastasis. 3. cream can inhibit lung tumor inhibition varying degrees of Lewis lung tumor growth and metastasis. The lung tumor inhibition cream can significantly reduce the value of VEGF, suggesting that lung tumor inhibition cream may inhibit the expression of VEGF and play a role in thetreatment of advanced lung adenocarcinoma. 5. Chinese medicine(lung tumor inhibition cream) plus chemotherapy compared with chemotherapy alone, whether in terms of improving the patient’s symptoms or have advantages in terms of tumor suppressor.