Develop Computer-assisted Memory Training Software And A Randomized Single-blind Pilot Study For Brain-damaged Patients

[Object]:The aim of present pilot study was to investigate the effect of computer-assisted memory training on memory function and activity of daily living in brain -damaged patients by the 2014 version memory training software, prepare the groud for further improvement of the software and for promotion of its clinical application.[Material and methods]:1.Forty three brain injury patients with memory impairment assessed by Mini-Mental-State Examination(MMSE) and Montreal Cognitive Assessment (MOCA)were randomly divided into two groups:memory software training group (TG, N=22)and control group (CG, N=21), the TG underwent 4 weeks of computer-assisted memory training that involved in visual and auditory stimulation and experience memory task related to daily life. The CG only underwent traditional memory training such as retrieval interval、elimination clues and so on. Both groups received the same medical therapy, physical therapy and occupational therapy.2.The memory test part of MMSE, MOCA.the Rivermead Behavioural memory test-Second Edition(RBMT-Ⅱ) and functional evaluation modify Bathel index(MBI) were performed at baseline and after 4 weeks training phase respectively. 3.To make the statistical analysis to deal with clinical research data, such as the mean± standard deviation, variance analysis, test and t-test.[Result]:1.At the beginning, there is no significant difference between the MMSE, MoCA, RBMT-Ⅱ and Bathel test. (P>0.05)2.The MMSE memory,MOCA delayed memory and MBI score shown, between the two groups, there was significant difference in training 4th week (P<0.05), and the score of training group higher than the control group. In each group, the score increased 4 weeks (P<0.05)3.The RBMT-Ⅱ score shown, between the two groups,there was significant difference in training 4th week (P<0.05), and the score of training group higher than the control group.In each group,there was no significant difference in control group (P>0.05).,but there was significant difference in training group (P<0.05)4.The MOCA other congnition score shown, between the two groups,there was significant difference in training 4th week (P<0.05), and the score of training group higher than the control group.In each group, there was no significant difference in both groups (P>0.05).[Conclusion]:1. Since the design of the memory disorder software is reasonable and easy to operate, it can be widely utilized in clinical intervention.2.Findings in this study support the memory training software, which was supposed to improve memory function and ADL function in patients with brain injury.3.The memory dusorder software is not effective for other cognition areas, so we should use other training methods for patients with other cognition disorders.