Clinico-Histopathological Correlation In New And Treatment Leprosy Patients In Yunnan Province

Objective:To investigating clinical manifestations and pathological characteristics of new leprosy cases. For the treatment of leprosy patients whose treatment period was enough to monitor, observing their clinical changes and characteristics of the pathological changes after treatment, evaluated the treatment effect and clinical cure.Methods:Collected 79 cases of leprosy patients who came to our hospital for diagnosis and review to make retrospectively analysis. Hematoxylin eosin(HE) stain and acid fast stain were done to collected tissue wax block, then observed the the pathological features and collected date. Finally, according to the collected the clinical and pathological data were statistically analyzed.Results:The new leprosy patients unexisted correlation between age and leprosy classification or bacteria. The rate of discordance between pathological classification and leprosy classification was 10%, whose pathological characteristics were nonspecific inflammatory. There was positively correlation between leprosy classification and granulomatous fraction(GF) (rs=0.323, P= 0.012), different leprosy classification had correlation with GF and had statistically significant (H=10.811, P=0.029). There was statistically significant of GF average between new group and treatment group(Z=-3.116, P= 0.002), and GF average of new group was higher than the treatment group.7 cases (11.67%) of the new cases of bacteria amount was less than the quantity pathological classification corresponding bacteria, which occurred in multibacillary leprosy (MB), with 3 cases of cataclastic bacteria and another 3 cases of Ⅱ leprosy reactions. The number of Ⅱ leprosy reaction in treatment group was more than in new group. The cure rate of leprosy patients who have completed the prescribed treatment was only 68%, and the unhealed patients were multibacillary leprosy.Conclusion:Leprosy patients were mostly young adults, and men were more than women. Age distribution of leprosy patients associated with different ages of cellular immune function and the opportunity of exposure to leprosy infection. Due to the leprosy diversity of clinical manifestations, early symptoms are not typical, and part no leprosy patients with pathological characteristics change, but it can’t exclude the possibility of leprosy, should be combined with clinical manifestations in patients with tissue fluid and acid fast stain, five, strive for the early diagnosis, missed diagnosis and misdiagnosis. Leprosy patients who completed the treatment, still need long-term monitoring, observe whether to achieve clinical cure, monitoring relapse, found no cure and recurrence patients in a timely manner.