Difference Of Pathological Indicators And Moleculor Subtypes Between Ductal Carcinoma In Suit And DCIS With Microinvasion

Objective: To compare clinicopathological features,immunohistochemical results and moleculor subtypes between DCIS and DCIS-Mi for investigating the possiab le pathological and biological alterations of DCIS PRogression to DCIS-Mi and s upply the PRognosis of DCIS and better clinical treatment methods.Methods:In this retrospective study.129 DCIS patients were recruited(included 69pure-DCIS, 60 DCIS-Mi).Tumor size,age,histopathological grade ER,PR,Her-2Ki-67 were collected for this study. According to 2011 ST.Gallen they were cate gorized into four groups luminal-A(ER+ and/or PR+,Her-2-,Ki-67≤14%),lumina l-B(ER+ and/or PR+,Her-2+-,Ki-67>14%),Her-2+(ER- and PR-, Her-2+)triple ne gative(ER- and PR-Her-2-).pearson χ2 and logical regression were applied for t he stactics.Results: 1,Large tumors size, highly graded,ER and PR positive,Ki-67>20%,ly mph nodes are all significantly different between pure-DCIS and DCIS-Mi(p< 0.05);while Her-2(+),tumor size,age are no significantly. 2,the ditribution of mole culor subtypes between them are obvious significent(p< 0.05).The PRoportion of luminal like and triple negitive tumors decreased, whereas Her-2 tumors incr eased in DCIS-Mi compared with pure DCIS. 3,The Her-2 subtype show more likely to micro-invasion than other subtype(OR=12.343,p=0.001).Conclusion:1,DCIS-Mi is a complex and heterogeneity disease as the same as D CIS and PRone to metastasis.2,when come to tumor size more than 2.5cm,ER/PR(-),Ki-67>20%,high grade, we should pay more attention to micro invasion and n eed more aggressive treatment 3,the molecular subtype in DCIS and DCIS-Mi ar e significantly different(p<0.05).the value of it need future investment.