The Effects On Serum Melatonin Level Of Newborn With The Blue Light Therapy

The effects on serum melatonin level of newborn with the blue light therapyBackgroundMelatonin is found in the pineal gland at the early time. With develop of medical and technology, melatonin is found also in gastrointestinal tract, the skin, the retina, and the eye lens,Because melatonin has high fat soluble and water soluble, it exests in humor, human tissue and cell membrane.There is recipient melatonin in spleen, thymus, lympy nodes, gonad,gastrointestinal tract, cardiovascular system,and kidney.Melatonin is one of the most important hormones, which takes part in various physiological and pathological process, affects biological rhythms, aging and endocrine hormone, adjusts immunity and protects important organs. light is a major way to adjust melatonin. Neonatal jaundice is a common disease. Blue light therapy is viewed as the first treatment method. For the solutions of the questions that whether the blue light therapy could affect melatonin, whether the diarrhea, rash and crying of the neonate is related to tthe change of Melatonin, and whether the blue light therapy would have a long-term influence, a further research is still needed.ObjectTo analyze the blue light therapy’s effects on newborn’s Melatonin and the relationship between the change of Melatonin and the diarrhea, and increasing of crying during the blue light therapy.Mothods30 neonates with neonate hyperbilirubinemia (total bilirubin less than 342μmol/L) hospitalized in neonatology department of maternal and child care service centre, including 16 male and 14 female, are taken as the observation objects. The neonates in this observation group never have neonatal infectious diseases, neonatal hemolysis disease, neonatal hypoxic ischemia encephalopathy, or sugar metabolic disorder.30 full term neonates born naturally in the obstetrical department of this center are taken as the control group, including 17 male and 13 female. Mothers should be healthy during their pregnancy, having no Gestational diabetes, or high blood pressure. The neonates themselves should have no perinatal asphyxia history, intrauterine retarded, or Infectious and metabolic disease. The observation group is given the blue light therapy for 12 hours. Femoral vein is taken at 09:00-10:00 and 21:00-22:00 (after the 12-hour blue light therapy). The umbilical artery of the control group is taken from the neonates born during 21:00-22:00 to test the Melatonin.ResultIt is statistically significant (t=11.56, p<0.05) that Melatonin of the neonates with neonate hyperbilirubinemia before the the blue light therapy (09:00-10:00) is quite different from that of the control group(21:00-22:00); while Melatonin of the neonates with neonate hyperbilirubinemia after the the blue light therapy (21:00-22:00)has no obvious difference(t=1.88,p>0.05) from that of the control group(21:00-22:00), Melatonin of the neonates with neonate hyperbilirubinemia of adverse reactions has has no obvious difference(t=1.59, p>0.05) from that of the control group(21:00-22:00) and with neonate hyperbilirubinemia of no adverse reactions(t=17.05,p>0.05),which are not statistically significant. And it is statistically significant (t=12.99, p<0.05) that Melatonin of the neonates with neonate hyperbilirubinemia before the the blue light therapy (09:00-10:00) is quite different from that after the blue light therapy(21:00-22:00).ConclusionThe change of the neonate’s melatonin level has circadian thythmicity.The light therapy has no effect on the change of melatonin level of neomate with hyperbilirubinemia.Diarrhea,crying and rash caused by light therapy have nothing to do with melatonin.