The Expression Of P53 And Ebp1 In Hepatocellular Carcinoma And Its Significance In Prognosis Of The Disease

OBJECTIVE:Liver cancer is more common in the digestive system, liver cancer morbidity and mortality accounted for 55% of new morbidity and mortality each year around the world. Hepatocellular carcinoma accounts for more than 80% of liver cancer, hepatocellular carcinoma (HCC, for short liver cancer) progress very rapidly, the prognosis is poor and threat to human health seriously. ErbB3 (HER3) belongs to the type I receptor tyrosine kinase (RTK) of erbB (HER) receptor family. The ErbB receptor family include epidermal growth factor receptor (EGFR), erbB2 (HER2/neu), erbB3 (HER3), and erbB4 (HER4). It is considered to be one of the most important receptor families that involved in tumor development and progression. It has been demonstrated ErbB express and /or activate aberrantly in a variety of human cancers,. And Ebp1, a new intracellular binding protein with ErbB3, was found in recent years, and associated with cell growth and proliferation. P53 gene is widely recognized as the tumor suppressor gene, but the gene’s mutation is oncogene. P53 gene is located on human chromosome 17, p13, is a phosphorylated protein within nuclear. The gene is high correlative with human tumors so far. Studies have shown that P53 gene is highly expressed in HCC, but its correlation analysis with the expression of P53 protein has not been reported. Therefore, this study detected the expression of P53 and Ebpl protein by immunohistochemical method in hepatocellular carcinoma tissues, explored the relationship between their expression and clinicopathological parameters, thus provide a theoretical basis for the targeted therapy of hepatocellular carcinoma.METHODS:immunohistochemical method (SP) was used to detect the expression of P53 and Ebpl protein in 66 HCC and 66 adjacent tissues.RESULTS:P53 protein and Ebp1 protein positive rate of HCC (48.5%,42.4%) was significantly higher in hepatocellular carcinoma than the positive rate of P53 protein and Ebpl protein in adjacent tissues (4.5%,7.6%)(P<0.05). Ebp1 and P53 protein expression were independent of patient age, tumor size, gender, and family history in HCC, but P53 and Ebp1 high expression were correlated with TNM stage and lymph node metastasis positively (P<0.05).CONCLUSION:1. P53 and Ebpl protein expression in hepatocellular carcinoma tissues was signifi- cantly higher than that in normal tissues adjacent to carcinoma.2. P53 and Ebpl protein expression were closely related with TNM stage and lymph node metastasis in hepatocellular carcinoma.3. P53 protein is correlated with Ebpl protein positive in hepatocellular carcinoma, and provide a theoretical basis for the targeted therapy of hepatocellular carcinoma...