| Objective:The aim of this study is to compare2-year efficacy between laparoscopic and open D2gastrectomy for advanced gastric cancer, and evaluate the technical safety and feasibility of laparoscoic D2gastrectomy for advanced gastric cancer.Methods:According to inclusion and exclusion criteria,24patients undergoing LG and25patients undergoing OG for AGC were enrolled between January2012and March2013. The age,gender,tumor size,type of gastrectomy,pTNM stages, operation time, estimated blood loss, number of lymph nodes harvested, post-operative stay, post-operative complications, recurrence patterns, and2-year survival rates were studied to assess outcome differences between the laparoscopic and open groups.Results:The age,gender,tumor size,type of gastrectomy and pTNM stages were similar between the two groups. The mean operation time was significantly longer in LG group(296.5±63.1min) than that in OG group(262.8±47.4min)(P=0.039). The mean estimated blood loss was significantly less in LG group(153.3±83.2ml) than that in OG group(236.8±130.8ml)(P=0.011).The mean number of lymph nodes harvested was 32.3±13.7in the laparoscopic group,35.1±9.2in the open group (P>0.05). The mean post-operative stay was significantly shorter in LG group(10.9±3.8d) than that in OG group(15.0±7.8d)(P=0.034).There were no significant differences in complications between the two groups (P>0.05). There were no significant differences in pattern of initial recurrence of gastric cancer between the two groups(P>0.05). The2-year disease-free survival rates were45.8%and52.0%respectively in the laparoscopic and open groups(P>0.05).Concusions:Laparoscopic D2gastrectomy is a feasible and safe procedure for advanced gastric cancer. The2-year disease-free survival after laparoscopic D2gastrectomy are similar to open surgery. |
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