Clinical Research Of Evaluating Efficacy Of Rosuvastatin In Combination With Aspirin For Carotid Atherosclerosis Using High-frequency Ultrasound

Objective To investigate the repeatability of detecting carotid intima-mediathickness(CIMT) and carotid atherosclerotic plaque using high-frequency ultrasound, thento observate and evaluate the CIMT of patents with carotid atherosclerosis those singleusing rosuvastatin or combined with aspirin and the effect of carotid atherosclerotic plaque.Methods Ninety patients diagnosed with carotid atherosclerotic from yancheng thirdPeople’s Hospital were randomly divided into Group A (n=30, oral rosuvastatin10mg·d-1plus aspirin100mg·d-1), GroupB (n=30, oral rosuvastatin10mg·d-1) and Group C (n=30, oral aspirin enteric-coated tablets100mg·d-1). All subjects were observed for low-fatdiet for6months. Carotid IMT, Crouse plaque score, the number of soft plaque and mixedplaque were detected by two different doctors using high-frequency ultrasound beforetreatment, then the ultrasound images were saved. Contrasting the differences of the databetween them.After treatment detecting the lesions again on contrasting previous imagesby the same doctor and contrasting the differences of the data between two doctors. CarotidIMT, Crouse plaque score, the number of soft plaque、mixed plaque and serum lipids weredetected before treatment and after6months.Using SPSS17.0software analysis the data.T-test was used to compare the two groups. χ2test was used to compare the three groups.P<0.05was considered to be statistically significant.Result1、CIMT (1.07±0.32) mm, Crouse plaque score (7.86±3.10) mm, the numberof soft plaque (2.15±0.72), mixed plaque (0.45±0.64) by doctor A before treatment.CIMT (1.05±0.45) mm, Crouse plaque score (7.74±2.98) mm, the number of soft plaque(2.13±0.69), mixed plaque (0.46±0.59) by doctor B before treatment. There were nosignificantly difference between the two groups(all P>0.05).CIMT (0.88±0.45) mm,Crouse plaque score (6.43±2.84) mm, the number of soft plaque(1.54±0.49), mixed plaque (0.34±0.51) by doctor A after6months. CIMT (0.86±0.27) mm, Crouse plaquescore (6.37±2.69) mm, the number of soft plaque (1.52±0.42), mixed plaque (0.35±0.57) by doctor B after6months. There were no significantly difference between the twogroups(all P>0.05).2、Compared with those before treatment，CIMT, Crouse plaque score, the number ofunstable plaque were significantly decreased in group A and group B (all P<0.05). The datawere no significantly difference in group C(all P>0.05).3、After treatment,CIMT was significantly lower in groupA and group B than that ingroup C(P<0.05). There was no difference of CIMT between group A and groupB(P>0.05). Crouse plaque score, the number of unstable plaque were significantly lowerin group A than those in group B and group C(P<0.05). Crouse plaque score, the number ofunstable plaque were significantly lower in group B than those in group C(P<0.05).Conclusion1、 The method is reproducible,easy and accurate in detecting CIMT andatherosclerotic plaque using high-frequency ultrasound.2、Rosuvastatin and aspirin have an anti-atherosclerosis effect,and rosuvastatin issuperior to aspirin;Combination therapy of rosuvastatin plus aspirin can exert significantlysynergistic effect.3、 High-frequency ultrasound can be used in evaluating treatment efficacy withanti-carotid atherosclerosis drugs.