Analysis Of Extended-Spectrum Beta Lactamases’Detection And Antibiotic Resistance Of Escherichia Coli Causing Bloodstream Infection

Objective To analyze the rate of Extended-Spectrum Beta Lactamases(ESBLs) producing and drug resistant characteristics of Escherichia coli (E. coli) causing bloodstream infection, provide evidence for rational use of clinical antibiotics.Methods During January2011to December2012, a total of96strains of E. coli were isolated from blood stream infection in Shangyu People’s Hospital. ESBLs detecting was performed by the standard disk diffusion method, and Kirby-Bauer disk diffusion method was applied to detect the drug susceptibility.Results The isolation rates of E. coli from blood culture samples were19.48%and17.4%, respectively in2011and2012. ESBLs productive rate of E. coli increased from60.00%to60.78%during the years from2011to2012. The resistance rates to most antimicrobials of ESBLs-producing strains were much higher than those of non-ESBLs-producing strains. Carbapenems were very sensitive against E. coli, no matter those were caused by ESBLs-positive or ESBLs-negative strains.Conclusion The detection rate of ESBLs-producing E. coli is relatively high, strains producing ESBLs remain high resistant to many antibiotics. It is feasible to empirically use carbapenems to treat bloodstream infection caused by E. coli.