The Correlation Of Blood Serum Adiponectin,blood Lipid And Blood Uric Acid Among Different TCM Syndromes Of Coronary Heart Disease

Objective: To observe the level changes of serum adiponectin,blood lipid and blood uric acid among different TCM syndrome types ofcoronary heart disease patients, and explore objective syndromedifferentiation indicators of coronary heart disease (CHD). Methods:Choosed66patients who were diagnosed by coronary angiography forcoronary heart disease randomly. There were40males,26females, age48-88years old, the average age of (67.65±10.65).These patients weredivided into different TCM syndromes according to the principle ofTCM clinical syndrome differentiation. In addition, collected18casesconsidered CHD by the doctor from outpatient service, but did not seecoronary stenosis in the CAG. There were11males,7females, age44-86, mean age (65.83±11.25) years old. Tested all of the above patientsserum APN, blood lipid and blood uric acid levels, and compared all thedata among non CHD group,CHD group and different TCM syndromes.1.Choosed66patients with coronary heart disease who were conformedto the diagnosis standard, and excluded the patients who didn’t meet thecriteria or didn’t have complete data.2. Recorded these patients’ generalinformation such as age, gender, body mass index, blood lipid,BUA and coronary angiography results, and divided these patients into non CHDgroup and CHD group. With reference to the TCM syndrome diagnosticcriteria of thoracic obstruction in2002"guiding principle of clinicalresearch on new drugs of TCM", these patients were divided into4groups: TCM Syndromes of blood stasis syndrome22cases, patients withsyndrome of phlegm blocking heart vessel in15cases, Yang Qideficiency syndrome in15cases,14cases of deficiency of both Qi andYin. There are excessive syndrome group (blood stasis syndrome andphlegm blocking heart vessel),37cases and deficiency syndromegroup(Yang Qi deficiency syndrome and deficiency of both Qi andYin),29cases.3. Seted up a control group of18cases of non CHD, tocompare the difference of serum adiponectin,blood lipid and BUAbetween CHD group and non CHD group.4. All hospitalized patientswere extracted fasting venous blood4ml the next morning, collectedserum by centrifugation, and stored it in low temperature.5.Determination of APN content: detected the APN content by ELISA andcompared it, observed the correlation between APN and TCM syndrometype of CHD.6. Data collecting, sorting and analysis: All datas werefirst recorded in Excel electronic form and then analyzed with SPSS19.0software package. Measurement data was showed by mean±standarddeviation. Mean comparison between two groups used two independentsample t test.Mean differences among multiple groups compared with F test firstly, when the difference was statistically significant, q test wasapplied to multiple comparisons; Count data used X2test. P>0.05, nosignificant difference; p <0.05,there were statistical differences;p<0.01,there were significant differences. Results:1.The comparetions ofage, sex, body mass index among CHD group, non CHD group anddifferent TCM syndrome types, in addition to qi and Yin deficiencysyndrome body mass index was lower than other syndrome types, wereno statistically significant differences (p>0.05). Each group of data wascomparable.2.Serum APN content of CHD group (15.21±5.96) ug/mlwas lower than the control group （26.14±6.18）ug/ml, the differencewas statistically significant (p<0.01).3. Each type of TCM Syndromespatients’ serum APN levels: blood stasis syndrome (17.60±6.91) ug/ml,phlegm blocking heart vessel syndrome (11.31±4.82) ug/ml, Yang Qideficiency syndrome (17.59±4.61) ug/ml, both Qi and yin deficiencysyndrome (13.36±4.47) ug/ml, the content of serum APN in differentsyndrome types were lower than non CHD group, the difference wasstatistically significant (p<0.01); The content of serum APN in phlegmblocking heart vessel syndrome and Qi and yin deficiency syndrome werelower than that of blood stasis syndrome and yang qi deficiencysyndrome group, the difference was statistically significant (p<0.01orp<0.05); The content of serum APN was no statistically significantdifference between phlegm blocking heart vessel syndrome and Qi and yin deficiency syndrome (p>0.05);At the same time, the serum APNcontent between blood stagnation syndrome and yang qi deficiencysyndrome had no statistical significance (p>0.05).4.The CHD group TC（4.22±0.95）mmol/L、TG (1.67±0.92) mmol/L、LDL （2.44±0.70）mmol/L levels were higher than that in non CHD group TC （3.96±0.86）mmol/L、TG (1.61±0.97) mmol/L、LDL （2.20±0.71）mmol/L；In different TCM syndromes of CHD, the levels of TC （4.43±1.05）mmol/L、TG (1.85±0.98) mmol/L、LDL （2.63±0.77）mmol/L inphlegm blocking heart vessel syndrome were higher than that in otherTCM syndromes, but there was no significant difference (p>0.05). Thelevel of BUA in CHD group (366.28±137.91)umol/L was higher thanthat in non CHD group (347.57±76.83)umol/L; In different TCMsyndromes of CHD, the level of BUA (342.00±98.86)umol/L was lowerthan that in other TCM syndromes; The level of BUA in deficiencysyndrome group (389.31±147.45)umol/L was higher than that inexcessive syndrome group (348.24±129.12)umol/L, but there was nosignificant difference (p>0.05).6. The results of this study did not find adifference of HDL, ApoA among non CHD group, CHD group anddifferent syndrome types. Conclusions:1. Serum adiponectin in CHDwas significantly lower than that in non CHD patients. The resultssuggested that detection of serum APN can predict the presence ofcoronary artery lesion to a certain extent.2. The serum APN levels in each TCM syndromes were significantly lower than those in the controlgroup, and there were differences between different TCM Syndromes ofserum APN content. The levels of serum APN in Syndrome of phlegmblocking heart vessel and qi and yin deficiency syndrome were lowerthan that in blood stasis syndrome and yang qi deficiency syndrome.APN is likely to become one of the objective indexes of TCM Syndromesof CHD.3. Blood lipids (TC, TG, LDL) and BUA in CHD group werehigher than that in non CHD group, and they had some difference indifferent TCM Syndromes. Although these differences were notstatistically significant in the present experimental results, we predictthat these differences exist according to other relevant literature studies.With the further research, Blood lipid (TC, TG, LDL) and BUA, may beused as objective reference index of TCM syndrome of CHD.4. Thisstudy has not yet found the difference of HDL, ApoA in non CHD group,CHD group and different TCM Syndromes. The results of this study needto be further expanded the experimental samples to obtain more sufficientevidence.We don’t know the relationship between HDL, ApoA and TCMsyndrome type of CHD.