Case-control Study On The Risk Factors Of Breast Cancer In Females Of Luzhou Area

Objective:A case control study on the risk factors of breastcancer in females of Luzhou City was conducted to provide scientific basis forthe study of the etiology of breast cancer and breast cancer prevention andcontrol work in Luzhou City.Methods:In this study,a1:1case-control studymethod was adopted and the subjects were134breast cancer cases selectedfrom breast surgery of Luzhou Medical College Hospital from January2013toDecember2013,matched the case group and the control group with ages.Univariate and multivariate logistic regression analysis were performed foranalyzing the risk factors of breast cancer.Results: The average age of thepatients with breast cancer and the control group were51.23±8.82and51.01±9.23and there was no statistical significance(t=0.493，P=0.834).The case groupand the control group were both Han Chinese of the same areas.Results ofunivariate analysis:The differences of profession distribution between the casegroup and the control group had statistical significance(P<0.05):Compared withfarmers,the profession of migrant workers（OR=3.216，95%CI：1.050~9.847）,workers （OR=9.323，95%CI：2.614~33.256）, business unit personnel（OR=5.423,95%CI：1.619~18.169）, business personne（lOR=4.569，95%CI：1.294~16.134）, etc.has a relationship with breast cancer;The differences ofmenstrual history between the case group and the control group had statistical significance(P<0.05):Irregular menstruation（OR=0.478，95%CI：0.233~0.981）and premature（OR=0.545，95%CI：0.307~0.969）have relationships withbreast cancer;The difference of the times of pregnancy and abortion betweenbreast cancer patients and the control group had statistical significance(P<0.05):Times of pregnancy（OR=1.544，95%CI：1.290~1.847）and times ofabortion（OR=2.284，95%CI：1.698~3.072） have relationships with breastcancer;The difference of nursing way between breast cancer patients and thecontrol group had statistical significance(P<0.05):Comparied withbreastfeeding,artificial feeding（OR=13.733，95%CI：1.804~104.527）has arelationship with breast cancer;The difference between breast cancer patientswith the history of benign breast disease, mammary gland hyperplasia,functional uterine bleeding history, family history of cancer and the controlgroup had statistical significance(P<0.05): The history of benign breast disease（OR=14.50，95%CI：3.46~60.767）, the history of mammary gland hyperplasia（OR=7.5，95%CI：1.715~32.796）, the history of functional uterine bleedinghistory（OR=5.50，95%CI：1.219~24.813）have relationships with breastcancer;The difference between breast cancer patients with history of drinking,smoking, and long time night shift exposure and the control group hadstatistical significance (P<0.05):Comparied with no smoking、drinking or nightshift, once smoking（OR=0.015，95%CI：0.001~0.205）, drinking（OR=0.055，95%CI：0.005~0.557）,night shift（OR=4.637,95%CI：1.543~13.930）haverelationships with breast cancer;The differences between breast cancer patients with three meals on time, dietary preferences, and exposure history of toxicsubstances and fresh fruit and the control group had statisticalsignificance(P<0.05):Comparied with eating disorders,bland diet,no fruit andexposure history toxic substances,three meals on time（OR=0.424，95%CI：0.227~0.793）,salty die（tOR=4.595,95%CI：1.681~12.559）,fresh fruit everyday（OR=0.353，95%CI：0.209~0.597）and the exposure history toxic substances（OR=2.133，95%CI：1.155~3.939） have relationships with breastcancer.Multi-factor analysis results:The differences of occupation, times ofabortion, mammary gland disease, functional uterine bleeding, three meals ontime, exposure history of toxic substances between the patients with breastcancer and the control group had statistical significance(P<0.05):Compariedwith farmers, workers（OR=15.105，95%CI：2.347~97.217）,business unit staffsuch as medical and civil servants, teachers,etc （OR=16.970，95%CI：2.741~105.057）,and students（OR=28.088，95%CI：1.649~478.51）haverelationships with breast cancer; Times of abortion（OR=2.721，95%CI：1.371~5.399）, breast benign disease（OR=26.822，95%CI：3.489~206.221）and exposure history to toxic substances in work （OR=4.059，95%CI：1.145~14.396） and three meals on time（OR=0.237，95%CI：0.061~0.921）have relationships with breast cancer.Conclusion: Workers, institution staff,student, times of abortion, breast benign disease and exposure to toxicsubstances in work are risk factors for breast cancer, meal on time is aprotection factor for breast cancer.