The Research Of Sini-San And Xiaoyao-San To The Behavior And Resistance Mechanism Of Depression Model Rats

Objective: To living alone in combination with chronic stress depression model of rats wasestablished, to explore the Sinisan and Xiaoyaosan anti-depressant mechanism.Methods: Ninety rats were randomly divided into nine groups: normal group (A), modelgroup (B), fluoxetine group (C), Sini low, medium and high dose groups (D1~D3),Xiaoyaosan low, medium and high dose groups (E1~E3). In addition to the A group, theremaining rats in each group56days of chronic stress stimulation. The first29days,except for groups A and B, for the rest of the group administered treatment. Day0, day28,day56rats in each group behavioral test, and once a week a fixed time measurement ofbody weight. Four weeks after administration, plasma level of CORT, ACTH, CRH levelsand changes in the hypothalamus, hippocampus neurotransmitter levels5-HT, DA and NEto calculate changes in the hippocampal BDNF, TrKB neuronal surface density values.Results: After28days of modeling, indexes A group of rats body weight, behavior wassignificantly higher than the other groups. After gavage treatment, in addition to A, groupB, the rats of these indicators have increased in varying degrees. For CORT, ACTH andCRH levels, the highest content of group B, A minimum; while the content of5-HT, DAand NE, the minimum group B, the highest in group A; Group B rat hippocampal BDNF,TrKB positive neurons areal density value is also significantly lower than the rest of thegroup, after28days of gavage treatment, the rats indicators change over varying degrees.Conclusion: Sinisan and Xiaoyaosan can improve the levels of CORT, ACTH,CRH,5-HT, NE and DA, increased expression of BDNF and TrKB in the hippocampus byadjust the hypothalamic-pituitary-adrenal (HPA) axis to reaching antidepressant effect.