Prognostic And Clinicopathological Significance Of MACC1Expression In Hepatocellular Carcinoma Patients: A Meta-analysis

Objective: Metastasis-associated in colon cancer-1(MACC1) has been reportedto be overexpressed in diverse human malignancies. However, the prognostic andclinicopathological value of MACC1in hepatocellular carcinoma (HCC) remainsinconclusive. Therefore, we conducted this meta-analysis to investigate theassociation between MACC1expression and the outcomes of HCC.Methods: Relevant articles were searched in PubMed, Embase, ScienceDirect,Cochrane Library, CNKI, Chinese Biomedical Literature, and Wanfang databasesupdated to March2015. The pooled hazard ratios (HRs) and odds ratios (ORs)with their95%confidence intervals (CIs) were assessed using STATA10.0, andthen the correlations of MACC1expression with overall survival (OS),disease-free survival (DFS), and clinicopathological features were analyzed.Results:9studies with a total of1,293HCC patients were included in thismeta-analysis. Our results showed that MACC1overexpression was significantlyassociated with poor OS (HR=2.30,95%CI1.47-3.59, univariate analysis; HR=2.39,95%CI1.49-3.82, multivariate analysis), poor DFS (HR=1.73,95%CI1.40-2.13, univariate analysis). Moreover, MACC1overexpression wassignificantly associated with AFP level (OR=1.31,95%CI1.03-1.68), tumor number (OR=1.37,95%CI1.07-1.75), differentiation (OR=2.37,95%CI1.46-3.83), TNM stage (OR=2.89,95%CI2.18-3.82), vascular invasion (OR=1.89,95%CI1.43-2.50), capsule invasion (OR=2.89,95%CI1.40-5.94), andmetastasis (OR=2.66,95%CI1.16-6.10).Conclusion: MACC1overexpression indicated poor survival rate, highrecurrence rate, and aggressive biological behaviors. MACC1can serve as anindicator of prognosis and a potential novel target for treatment in HCC patients.